Journal ArticleDOI
Thyrotropin-releasing hormone in the gastrointestinal tract
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TRH immunoreactivity has been shown to occur throughout the rat gastrointestinal tract and is destroyed by fresh human serum, and co-chromatographs with TRH on a Sephadex G-10 column and on a SP SephADEx C-25 column.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1977-11-07. It has received 183 citations till now. The article focuses on the topics: Thyrotropin-releasing hormone & Gastrointestinal tract.read more
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The neuroendocrine control of appetite: the role of the endogenous opiates, cholecystokinin, TRH, gamma-amino-butyric-acid and the diazepam receptor.
TL;DR: A number of similarities and minor differences between the monoaminergic and peptidergic control of appetite and the central control of analgesia and temperature regulation suggests the possibility that there may be a degree of nonspecificity in the control of these closely related life-sustaining processes.
Journal ArticleDOI
Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.
Timothy C. Wang,Susan Bonner-Weir,PS Oates,M Chulak,B Simon,G T Merlino,EV Schmidt,S J Brand +7 more
TL;DR: This transgenic study suggests that islet neogenesis can be reactivated in the ductular epithelium of the adult pancreas by local expression of two growth factors, gastrin and TGF alpha.
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Extrahypothalamic Thyrotropin Releasing Hormone (TRH) — Its distribution and its functions
TL;DR: One of the metabolites of TRH histidyl-proline diketopiperazone, appears to have a number of extrahypothalamic actions and this suggests the need for further exploration of the affects of this compound both on the central nervous system and the gastrointestinal tract.
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On the neuropharmacology of thyrotropin releasing hormone (TRH).
TL;DR: It would appear from the available information that a unifying hypothesis regarding the mode of action of TRH is not available to account for the multiple neurobiological effects of this peptide, but a facilatory interaction ofTRH with central cholinergic mechanisms may at least partially account for several of the actions of TRh including its remarkable antinarcosis effects.
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The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker
TL;DR: Preliminary evidence suggests that TSH blunting in depression may be related to duration of illness, history of violent suicide attempts, and a reduced 24 h TSH secretion.
References
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The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the apud series and the embryologic, physiologic and pathologic implications of the concept
TL;DR: A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics which indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms.
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Thyrotropin-releasing hormone (TRH): distribution in hypothalamic and extrahypothalamic brain tissues of mammalian and submammalian chordates
TL;DR: Findings indicate that TRH is distributed throughout the vertebrate kingdom, and has an ancient lineage.
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Enkephalin-like immunoreactivity in the human gastrointestinal tract
TL;DR: Enkephalin-like immunoreactivity was present in all areas of the gut with particularly high concentration in the antrum and significant amounts in the upper small intestine.