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Top ten biotechnologies for improving health in developing countries

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TLDR
An international group of eminent scientists with expertise in global health issues was asked to identify the top ten biotechnologies for improving health in developing countries, and the results offer concrete guidance to those in a position to influence the direction of research and development.
Abstract
Most research into genomics and other related biotechnologies is concerned with the priorities of industrialized nations, and yet a limited number of projects have shown that these technologies could help improve health in developing countries. To encourage the successful application of biotechnology to global health, we carried out a study in which we asked an international group of eminent scientists with expertise in global health issues to identify the top ten biotechnologies for improving health in developing countries. The results offer concrete guidance to those in a position to influence the direction of research and development, and challenge common assumptions about the relevance and affordability of biotechnology for developing countries.

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Patterned Paper as a Platform for Inexpensive, Low‐Volume, Portable Bioassays

TL;DR: This communication describes a simple method for patterning paper to create well-defined, millimeter-sized channels, comprising hydrophilic paper bounded by hydrophobic polymer, that will become the basis for low-cost, portable, and technically simple multiplexed bioassays.
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Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices

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Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis.

TL;DR: A prototype system for quantifying bioassays and for exchanging the results of the assays digitally with physicians located off-site offers new opportunities for inexpensive monitoring of health, especially in situations that require physicians to travel to patients to obtain diagnostic information that might be obtained more effectively by less valuable personnel.
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Three-dimensional microfluidic devices fabricated in layered paper and tape.

TL;DR: A method for fabricating 3D microfluidic devices by stacking layers of patterned paper and double-sided adhesive tape to carry out a range of new analytical protocols simply and inexpensively without external pumps is described.
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Lab-on-a-chip devices for global health: Past studies and future opportunities

TL;DR: This review identifies diseases that are most in need of new health technologies, special design criteria for LOC devices to be deployed in a variety of resource-poor settings, and review past research into LOC devices for global health.
References
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Book

Gazing into the oracle : the Delphi method and its application to social policy and public health

Erio Ziglio, +1 more
TL;DR: Theoretical, Methodological and Practical Issues Arising out of the Delphi Method, Armando Rotondi and David Gustafson.
Journal ArticleDOI

Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs

TL;DR: A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria and the presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprene biosynthesis in P. falcIParum depends on the DOXP pathway.
Journal ArticleDOI

Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

TL;DR: The novel 11-kDa virucidal protein, named cyanovirin-N (CV-N), is isolated and sequenced from cultures of the cyanobacterium (blue-green alga) Nostoc ellipsosporum and is highly resistant to physicochemical denaturation, further enhancing its potential as an anti-HIV microbicide.
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