Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent.
Kristell L.S. Chatalic,Sandra Heskamp,Mark Konijnenberg,Janneke D.M. Molkenboer-Kuenen,Gerben M. Franssen,Marian C. Clahsen-van Groningen,Margret Schottelius,Hans-Jürgen Wester,Wytske M. van Weerden,Otto C. Boerman,Marion de Jong +10 more
TLDR
The preclinical application of PSMA I&T, a DOTAGA-chelated urea-based PSMA inhibitor, for SPECT/CT imaging and radionuclide therapy of prostate cancer is presented and indicates that PSMA-specific uptake in kidneys can be successfully tackled using blocking agents such as 2-PMPA.Abstract:
Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are excellent candidates for PCa theranostics-they rapidly and efficiently localize in tumor lesions. However, high tracer uptake in kidneys and salivary glands are major concerns for therapeutic applications. Here, we present the preclinical application of PSMA IT however, high renal and spleen uptake in control mice (no 2-PMPA) interfered with visualization of metastases in the vicinity of those organs. Coadministration of 2-PMPA increased the tumor-to-kidney absorbed dose ratio during (177)Lu-PSMA I&T radionuclide therapy. Hence, at equivalent absorbed dose to the tumor (36 Gy), coinjection of 2-PMPA decreased absorbed dose to the kidneys from 30 Gy to 12 Gy. Mice injected with (177)Lu-PSMA I&T only, showed signs of nephrotoxicity at 3 months after therapy, whereas mice injected with (177)Lu-PSMA I&T + 2-PMPA did not. These data indicate that PSMA I&T is a promising theranostic tool for PCa. PSMA-specific uptake in kidneys can be successfully tackled using blocking agents such as 2-PMPA.read more
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Radioactive Transition Metals for Imaging and Therapy.
TL;DR: This Review provides an overview of some of the ways that new technologies, primarily related to radionuclide production, have provided solutions to these problems and several historical examples of the limitations of earlier metalloradiopharmaceuticals.
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131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment
Matthias D'Huyvetter,Jens De Vos,Catarina Xavier,Marek Pruszynski,Yann G.-J. Sterckx,Sam Massa,Sam Massa,Geert Raes,Geert Raes,Vicky Caveliers,Michael R. Zalutsky,Tony Lahoutte,Nick Devoogdt +12 more
TL;DR: The generation of a 131I-labeled sdAb as a theranostic drug to treat HER2-overexpressing cancer and demonstrate the theranostics potential of [131I]SGMIB-2Rs15d could impact therapy outcome on HER2+ breast cancer patients.
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Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine.
Yan Wang,Qian Tong,Jia-Wen Shou,Zhen-Xiong Zhao,Xiao-Yang Li,Xian-Feng Zhang,Shu-Rong Ma,Chi-Yu He,Yuan Lin,Bao-Ying Wen,Fang Guo,Jie Fu,Jian-Dong Jiang +12 more
TL;DR: It is shown here that feeding hamsters with high fat diet (HFD) caused an increase in blood lipids and NR activity in the intestine and the fecal NR activity might serve as a biomarker in the personalized treatment of hyperlipidemia using BBR.
Journal ArticleDOI
The 68Ga/177Lu theragnostic concept in PSMA targeting of castration-resistant prostate cancer: correlation of SUVmax values and absorbed dose estimates
Lorenza Scarpa,Sabine Buxbaum,Dorota Kendler,Katharina Fink,Jasmin Bektic,Leonhard Gruber,Clemens Decristoforo,Christian Uprimny,Peter Lukas,Wolfgang Horninger,Irene Virgolini +10 more
TL;DR: Dosimetry is mandatory for a patient-specific approach following 177Lu-PSMA617 therapy for patients with metastatic castration-resistant prostate cancer (mCRPC).
Journal ArticleDOI
Enhancing Treatment Efficacy of 177Lu-PSMA-617 with the Conjugation of an Albumin-Binding Motif: Preclinical Dosimetry and Endoradiotherapy Studies.
Hsiou-Ting Kuo,Helen Merkens,Zhengxing Zhang,Carlos Uribe,Joseph Lau,Chengcheng Zhang,Nadine Colpo,Kuo-Shyan Lin,Francois Benard +8 more
TL;DR: A novel albumin-binder-conjugated 177Lu-PSMA-617 derivative with an extended blood retention time to maximize the radiation dose delivered to prostate tumors expressing prostate-specific membrane antigen (PSMA) warrants further investigation for endoradiotherapy of prostate cancer.
References
More filters
Journal ArticleDOI
Cancer treatment and survivorship statistics, 2012
Rebecca L. Siegel,Carol DeSantis,Katherine S. Virgo,Kevin Stein,Angela B. Mariotto,Tenbroeck Smith,Dexter L. Cooper,Ted Gansler,Catherine C. Lerro,Stacey A. Fedewa,Chun Chieh Lin,Corinne R. Leach,Rachel S. Cannady,Hyunsoon Cho,Steve Scoppa,Mark Hachey,Rebecca A. Kirch,Ahmedin Jemal,Elizabeth Ward +18 more
TL;DR: Common cancer treatments, survival rates, and posttreatment concerns are summarized and the new National Cancer Survivorship Resource Center is introduced, which has engaged more than 100 volunteer survivorship experts nationwide to develop tools for cancer survivors, caregivers, health care professionals, advocates, and policy makers.
Journal ArticleDOI
EAU Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent—Update 2013
Axel Heidenreich,Patrick J. Bastian,Joaquim Bellmunt,Michel Bolla,Steven Joniau,Theodor van der Kwast,Malcolm David Mason,Vsevolod Matveev,Thomas Wiegel,Filiberto Zattoni,Nicolas Mottet +10 more
TL;DR: Current evidence is insufficient to warrant widespread population-based screening by prostate-specific antigen (PSA) for PCa, and watchful waiting is a treatment alternative to androgen-deprivation therapy (ADT), with equivalent oncologic efficacy.
Journal Article
Prostate-specific membrane antigen expression in normal and malignant human tissues.
TL;DR: The decrease in PSMA immunoreactivity noted in advanced prostate cancer suggests that expression of this molecule may be linked to the degree of tumor differentiation and the neoexpression of PSMA in endothelial cells of capillary beds in certain tumors may be related to tumor angiogenesis and suggests a potential mechanism for specific targeting of tumor neovasculature.
Journal ArticleDOI
EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer ☆
Nicolas Mottet,Joaquim Bellmunt,Michel Bolla,Steven Joniau,Malcolm David Mason,Vsevolod Matveev,Hans-Peter Schmid,Theo van der Kwast,Thomas Wiegel,Filiberto Zattoni,Axel Heidenreich +10 more
TL;DR: A summary of the 2010 version of the EAU guidelines on the treatment of advanced, relapsing, and castration-resistant prostate cancer (CRPC) summarise the most recent findings and put them into clinical practice.
Journal ArticleDOI
The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
Ali Afshar-Oromieh,Eleni Avtzi,Frederik L. Giesel,Tim Holland-Letz,Heinz G. Linhart,Matthias Eder,Michael Eisenhut,Silvan Boxler,Boris Hadaschik,Clemens Kratochwil,Wilko Weichert,Klaus Kopka,Jürgen Debus,Uwe Haberkorn +13 more
TL;DR: 68Ga-PSMA-ligand PET/CT can detect recurrent PCa in a high number of patients and can help delay systemic therapy of PCa.
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