Journal ArticleDOI
Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study
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TLDR
The combined results indicate a sufficiently low toxicity of cucurbit[n] as additives for medicinal and pharmaceutical use, and the bioadaptability of the compounds was further examined through in vivo studies on mice.Abstract:
Cucurbit[n]urils (CB[n]) are potential stabilizing, solubilizing, activating, and delivering agents for drugs. The toxicity of the macrocyclic host molecules cucurbit[7]uril (CB[7]), the most water-soluble homologue, as well as cucurbit[8]uril (CB[8]) has been evaluated. In vitro studies on cell cultures revealed an IC50 value of 0.53 ± 0.02 mM for CB[7], corresponding to around 620 mg of CB[7] per kg of cell material. Live-cell imaging studies performed on cells treated with subtoxic amounts of CB[7] showed no detrimental effects on the cellular integrity as assessed by mitochondrial activity. For CB[8], no significant cytotoxicity was observed within its solubility range. The bioadaptability of the compounds was further examined through in vivo studies on mice, where intravenous administration of CB[7] showed a maximum tolerated dosage of 250 mg kg−1, while oral administration of a CB[7]/CB[8] mixture showed a tolerance of up to 600 mg kg−1. The combined results indicate a sufficiently low toxicity to encourage further exploration of CB[n] as additives for medicinal and pharmaceutical use.read more
Citations
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Journal ArticleDOI
Chemical Sensors Based on Cucurbit[n]uril Macrocycles
Stephan Sinn,Frank Biedermann +1 more
Journal ArticleDOI
Red emitting, cucurbituril-capped, pH-responsive conjugated oligomer-based nanoparticles for drug delivery and cellular imaging.
TL;DR: The synthesis of nanoparticles based on a conjugated oligomer which is synthesized through Heck-coupling of divinylfluorene and dibromobenzothiodiazole monomers are reported, found to be stable in water for a prolonged time without forming any aggregates and could carry camptothecin, an anticancer drug with high loading efficiency.
Journal ArticleDOI
Drug Delivery by Controlling a Supramolecular Host–Guest Assembly with a Reversible Photoswitch
Nuno Basílio,Uwe Pischel +1 more
TL;DR: The reversibly switchable trans-chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug-cucurbit[7]uril host-guest assembly and the phototriggered release of memantine under illumination at 366 nm was observed.
Journal ArticleDOI
Enhanced in vitro and in vivo uptake of a hydrophobic model drug coumarin-6 in the presence of cucurbit[7]uril
Xiaoqing Miao,Ye Li,Ian Wyman,Simon Ming-Yuen Lee,Donal H. Macartney,Ying Zheng,Ruibing Wang +6 more
TL;DR: C cucurbit[7]uril-assisted quantitative in vitro and in vivo uptake of a hydrophobic model drug, coumarin-6, by both an epithelial cell model and a zebrafish model is described.
Journal ArticleDOI
Complexation of clofazimine by macrocyclic cucurbit[7]uril reduced its cardiotoxicity without affecting the antimycobacterial efficacy
Shengke Li,Judy Yuet-Wa Chan,Yan Li,David Bardelang,Jun Zheng,Wing Wai Yew,Denise P. Chan,Simon Ming-Yuen Lee,Ruibing Wang +8 more
TL;DR: The inherent cardiotoxicity of CFZ was dramatically reduced to almost nil in the presence of CB,[7], demonstrating the significant potential of CB[7] as a functional pharmaceutical excipient.
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