Trail Making Test Part A and Brain Perfusion Imaging in Mild Alzheimer's Disease
Aki Shindo,Seishi Terada,Shuhei Sato,Chikako Ikeda,Shigeto Nagao,Etsuko Oshima,Osamu Yokota,Yosuke Uchitomi +7 more
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TLDR
The results suggest that functional activity of the bilateral superior parietal lobules is closely related to performance time on the TMT-A, which might be a promising index of dysfunction of the superiorParietal area among mild AD patients.Abstract:
Background/Aims: The Trail Making Test (TMT) has long been used to investigate deficits in cognitive processing speed and executive function in humans. However, tread more
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SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Gwenaëlle Douaud,Soojin Lee,Fidel Alfaro-Almagro,Christoph Arthofer,Chaoyue Wang,Paul David McCarthy,Frederik J Lange,Jesper L. R. Andersson,Ludovica Griffanti,Eugene P. Duff,Saad Jbabdi,Bernd Taschler,Peter Keating,Anderson M. Winkler,Paul M. Matthews,Naomi E. Allen,Karla L. Miller,Thomas E. Nichols,Stephen M. Smith +18 more
TL;DR: In this paper , the authors investigated brain changes in 785 participants of UK Biobank (aged 51-81 years) who were imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans-with 141 days on average separating their diagnosis and the second scan-as well as 384 controls.
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Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Jennifer C. Felger,Zhihao Li,Ebrahim Haroon,Bobbi J. Woolwine,Moon Y. Jung,Xiaoping Hu,Andrew H. Miller +6 more
TL;DR: It is suggested that decreased corticostriatal connectivity may serve as a target for anti-inflammatory or pro-dopaminergic treatment strategies to improve motivational and motor deficits in patients with increased inflammation, including depression.
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Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery
TL;DR: In this paper , the effects of regional anesthesia on the incidence of postoperative delirium compared with general anesthesia were investigated in older adults undergoing surgical repair for hip fracture, in a randomized, allocation-concealed, open-label, multicenter clinical trial of 950 patients, with or without preexisting dementia, and a fragility hip fracture requiring surgical repair from 9 university teaching hospitals in Southeastern China.
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Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)
Roberto Bernabei,Francesco Landi,Riccardo Calvani,Matteo Cesari,Susanna Del Signore,Stefan D. Anker,R. Bejuit,Philippe Bordes,Antonio Cherubini,Alfonso J. Cruz-Jentoft,Mauro Di Bari,Tim Friede,Carmen Gorostiaga Ayestarán,H Goyeau,Palmi V. Jonsson,Makoto Kashiwa,Fabrizia Lattanzio,Marcello Maggi,Luca Mariotti,Ram R. Miller,Leocadio Rodríguez-Mañas,Regina Roller-Wirnsberger,Ingrid Rýznarová,Joachim Scholpp,Annemie M. W. J. Schols,Cornel C. Sieber,Alan J. Sinclair,Anna Skalska,Timo E. Strandberg,Achille Edem Tchalla,Eva Topinkova,Matteo Tosato,Bruno Vellas,Stephan von Haehling,Marco Pahor,Ronenn Roubenoff,Emanuele Marzetti +36 more
TL;DR: A multicomponent intervention based on physical activity with technological support and nutritional counselling prevents mobility disability in older adults with physical frailty and sarcopenia and was associated with a reduction in the incidence of mobility disability at 24 and 36 months.
References
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“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
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Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Book
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
Otfried Spreen,Esther Strauss +1 more
TL;DR: In this paper, the authors present a comprehensive assessment of mood, personality and adaptive functions of individuals in terms of test scores and scores of motor function, executive function, and attention.
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The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Jeffrey L. Cummings,Michael S. Mega,Kevin F. Gray,S. Rosenberg-Thompson,Daniela Carusi,Jeffrey Gornbein +5 more
TL;DR: The NPI has the advantages of evaluating a wider range of psychopathology than existing instruments, soliciting information that may distinguish among different etiologies of dementia, differentiating between severity and frequency of behavioral changes, and minimizing administration time.