Patent
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
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TLDR
The cloning of a eucaryotic promoter-regulatory region that functions preferentially in human cells is described in this paper, which is exemplified by a section of the human cytomegalovirus genome comprising a DNA sequence with regulatory and promoter signals.Abstract:
The cloning of a eucaryotic promoter-regulatory region that functions preferentially in human cells is disclosed. The invention is exemplified by the cloning of a section of the human cytomegalovirus genome comprising a DNA sequence with regulatory and promoter signals and an initiation site for RNA synthesis. The fragment, termed the human cytomegalovirus (HCMV) promoter-regulatory sequence, was obtained from purified HCMV DNA.read more
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Patent
Binding domain-immunoglobulin fusion proteins
TL;DR: In this paper, binding domain-immunoglobulin fusion proteins are defined as proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, and can be recombinantly produced at high expression levels.
Patent
Human antibodies that bind human IL-12 and methods for producing
Jochen G. Salfeld,Michael Roguska,Michael Paskind,Subhashis Banerjee,Daniel E. Tracey,Michael White,Zehra Kaymakcalan,Boris Labkovsky,Paul Sakorafas,Geertruida M. Veldman,Amy Venturini,Angela Widom,Stuart Friedrich,Nicholas W. Warne,Angela Myles,John Gawain Elvin,Duncan Alexander R,Elaine J. Derbyshire,Sara Carmen,Stephen Smith,Thor Las Holtet,Sarah Leila Du Fou +21 more
TL;DR: In this paper, human antibodies, preferably recombinant human antibodies that specifically bind to human interleukin-12 (hIL-12) are disclosed, which can be a full-length antibody or an antigen-binding portion thereof.
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Binding constructs and methods for use thereof
TL;DR: In this article, binding domain-immunoglobulin fusion proteins are defined, which can be recombinantly produced at high expression levels and are capable of ADCC and/or CDC while occurring predominantly as polypeptides compromised in their ability to form disulfide-linked multimers.
Patent
Moving sectors within a block of information in a flash memory mass storage architecture
TL;DR: In this article, a device is disclosed for storing mapping information for mapping a logical block address identifying a block being accessed by a host to a physical block address, identifying a free area of nonvolatile memory, the block being selectively erasable and having one or more sectors that may be individually moved.
References
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Journal ArticleDOI
Organization and Expression of Eucaryotic Split Genes Coding for Proteins
R Breathnach,P Chambon +1 more
TL;DR: This paper organizes the organization of protein codes into split genes, a small number of which are expressed in the chickenuct, and discusses generalization, generalization and Molecular Evolution.
Journal ArticleDOI
Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids
Arnold J. Berk,Phillip A. Sharp +1 more
TL;DR: A simple and sensitive method for detecting, sizing and mapping RNA transcripts from viral or cloned DNAs has been developed and used to examine the cytoplasmic transcripts produced during the early phase of adenovirus 2 (Ad2) infection of HeLa cells.
Journal ArticleDOI
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
TL;DR: It is proposed that this tissue-specific enhancer contributes to the activation of somatically rearranged immunoglobulin variable region genes and possibly to abnormal expression of other genes (e.g. c-myc) that become translocated to its domain of influence.
Journal ArticleDOI
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
TL;DR: The DNA sequences derived from the germ line JH-C mu region are found to be required for accurate and efficient transcription from a functionally rearranged VH promoter, and the Ig gene enhancer appears to act in a tissue-specific manner.
Journal ArticleDOI
DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract
TL;DR: A cell-free system for studying the synthesis of mRNA in mammalian cells, which consists of a dialyzed and concentrated whole-cell extract derived from HeLa cells, small molecules and cofactors needed for transcription, and exogenously added DNA.