Transformation of Mangiferin to Norathyriol by Human Fecal Matrix in Anaerobic Conditions: Comprehensive NMR of the Xanthone Metabolites, Antioxidant Capacity, and Comparative Cytotoxicity Against Cancer Cell Lines:
José R. R. Souza,José R. R. Souza,Maria Teresa Salles Trevisan,Maria Teresa Salles Trevisan,Judith P.A. Feitosa,Nágila M.P.S. Ricardo,William E. Hull,Gerhard Erben,Gerd Würtele,Andrea Breuer,Eva Frei,Cornelia M. Ulrich,Robert W. Owen +12 more
TLDR
Mangiferin metabolites were identified and quantitated in the fermentation broths by high performance liquid chromatography–diode array detection–electrospray ionization-mass spectrometry, and structures confirmed unequivocally by nuclear magnetic resonance, after purification by semipreparative HPLC.Abstract:
Several natural drugs (termed prodrugs) when administered orally undergo transformation by intestinal bacteria, producing metabolites, which may be more active than the parent compound. Mangiferin ...read more
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Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems-A Novel Research Direction.
TL;DR: In this paper, a review of the molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems is presented, and they conclude that mangiferin is a very promising anti cancer molecule with excellent properties and the absence of toxicity.
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In Vitro Gastrointestinal Digestion and Colonic Catabolism of Mango (Mangifera indica L.) Pulp Polyphenols.
José Luis Ordóñez-Díaz,Alicia Moreno-Ortega,Francisco Javier Roldán-Guerra,Víctor Ortíz-Somovilla,José Manuel Moreno-Rojas,Gema Pereira-Caro +5 more
TL;DR: The extensive transformation of mango pulp polyphenols through the gastrointestinal tract and by the resident gut microbiota is highlighted, with the resultant formation of mainly simple phenolics, which can be considered as biomarkers of the colonic metabolism of mango.
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Metabolism of mangiferin by human intestinal bacteria in vitro
TL;DR: Mangiferin can be metabolized in vitro by human intestinal bacteria into its aglycone (1, 3, 6, 7-tetrahydroxyxanthen) by MS and NMR.
Journal ArticleDOI
Использование метода капиллярного электрофореза при определении количественного содержания мангиферина в траве видов рода копеечник (Hedysarum caucasicum M.Bieb., Hedysarum grandiflorum Pall., Hedysarum daghestanicum Rupr. ex Boiss.) флоры Северного Кавказа
Д. Р. Имачуева,Ф. К. Серебряная +1 more
TL;DR: In this article, the authors developed a method for the quantitative determination of mangiferin in the aboveground part of species of the genus Hedysarum L. collected in the North Caucasus by zonal capillary electrophoresis.
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Aerobic bioconversion of C-glycoside mangiferin into its aglycone norathyriol by an isolated mouse intestinal bacterium
TL;DR: In this article, the authors isolated a mangiferin-deglycosylating bacterium strain KM7-1 from the mouse intestine, which belongs to the Bacillus genus.
References
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Prodrugs: design and clinical applications
Jarkko Rautio,Hanna Kumpulainen,Tycho Heimbach,Reza Oliyai,Doo-Man Oh,Tomi Järvinen,Jouko Savolainen +6 more
TL;DR: The most common functional groups that are amenable to prodrug design are described, and examples of prodrugs that are either launched or are undergoing human trials are highlighted.
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Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene
TL;DR: The aim of this study was to evaluate the phenolic antioxidant and squalene content in a range of olive and seed oils, and both the nature and source of olive oil consumed should be differentiated in ascertaining cancer risk.
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Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.).
Jacqueline C. Barreto,Maria Teresa Salles Trevisan,William E. Hull,Gerhard Erben,Edy Sousa de Brito,B. Pfundstein,Gerd Würtele,Bertold Spiegelhalder,Robert W. Owen +8 more
TL;DR: Mangiferin, detected at high concentrations in young leaves, in bark, and in old leaves (Itamaraka = 94 g/kg), shows an exceptionally strong antioxidant capacity.
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Formulation strategies for absorption windows.
TL;DR: Methods to increase the residence of drug formulations at or above the absorption window are discussed in this review, including bioadhesive microspheres that have a slow intestinal transit and the gastroretentive dosage system, which is based on multiparticulates or large single unit systems.
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Identification of Lignans as Major Components in the Phenolic Fraction of Olive Oil
TL;DR: Lignans, as natural components of the diet, may be important modulators of cancer chemopreventive activity and are shown for the first time that the lignans (+)-1-acetoxypinoresinol and (+)-pinoresinols are major components ofThe phenolic fraction of olive oils.