Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
Citations
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Book ChapterDOI
Animal Models of Stroke
TL;DR: A comprehensive and critical overview of the animal models of global and focal cerebral ischemia can be found in this article, where the applicability of animal models to the context of human stroke is examined.
Book ChapterDOI
Atraumatic Transient Focal Cerebral Ischemia in Monkeys
R. M. Crowell,Y. Olsson +1 more
TL;DR: This work has shown that abundant collateral blood supply exists distal to the circle of Willis, and that cerebral tissue may be much more resistant to diffuse ischemia than has previously been recognized.
Journal ArticleDOI
Cerebral Microangiography After Hypocarbia and Hypercarbia
TL;DR: Microangiography was shown to be useful in the study of dynamic vascular changes in the deep structures of the ischemic brain.
Progress in Cerebrovascular Disease Experimental Ischemic Stroke: A Review
TL;DR: This selective review of experimental stroke is based on an analysis of medical literature dealing with the induction of localized brain lesions through the occlusion of a single artery, finding that ischemic stroke is the most important condition of this group.
Journal ArticleDOI
Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia.
TL;DR: The results show that Fluosol-DA and hetastarch improve local CBF and EEG power data in ischaemic brain.
References
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Journal ArticleDOI
Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
Journal ArticleDOI
The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
Journal ArticleDOI
Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.