Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
Citations
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Journal ArticleDOI
Qualitative measurement of cerebral infarction using ultraviolet fluorescence.
TL;DR: A reliable method of macroscopically determining the volume of cerebral infarction using ultraviolet fluorescence was developed in an animal model and revealed that the areas of ischemic cell necrosis corresponded to areas of maximal fluorescence.
Book ChapterDOI
Cortical and Thalamic Somatosensory Evoked Potentials in Brain Ischemia in the Monkey
TL;DR: The chapter explains that CBF diaschisis is not common in monkeys and that EEG dias chisis occurs less frequently than CBFs, and the different components of the cortical SSEP provides useful information on the localization of the infarcted cortical area.
Journal ArticleDOI
An anatomical and pathological evaluation of middle cerebral artery occlusion in rats.
TL;DR: In this study, adult male Sprague-Dawley rats used for studying the anatomy of the horizontal segment of middle cerebral artery and infarct area after occlusion of the artery were able to achieve 92.5% grade III and IV infarCTed area.
Journal ArticleDOI
Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques.
Koichi Hara,Takao Yasuhara,Mina Maki,Noriyuki Matsukawa,Guolong Yu,Lin Xu,Laura Tambrallo,Nancy A. Rodriguez,David M. Stern,Tetsumori Yamashima,Jerry J. Buccafusco,Takeshi Kawase,David C. Hess,Cesario V. Borlongan +13 more
TL;DR: An anomaly of the aortic arch in some Rhesus macaques is reported that appears as a key surgical factor in ensuring the success of the TGI model in this particular NHP and warrants a critical surgical maneuver in order to produce consistent TGI-induced hippocampal cell loss.
References
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Journal ArticleDOI
Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
Journal ArticleDOI
The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
Journal ArticleDOI
Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.