Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
Citations
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Effect of neutralization of rat IL-6 bioactivity on collateral blood supply from retrograde flow via cortical anastomoses in the rat central nervous system.
TL;DR: The results suggest that neutralization of rat IL-6 bioactivity in longterm recovery increases the collateral blood supply from retrograde flow via cortical anastomoses after experimental arterial occlusion in the rat brain.
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Perivascular hemorrhagic lesions in temporal cortex following cerebral infarction (a morphological study)
Ronald F. Dodson,Yasuo Kawamura +1 more
TL;DR: It was concluded that diapedesis and extravasation in squirrel monkeys following transorbital occlusion of the middle cerebral artery had resulted from permeability changes in larger vessels.
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Changes in local cerebral blood flow, local EEG, and flow in the distal stump of the middle cerebral artery in cats with occlusion of the middle cerebral artery
TL;DR: The local EEG, the local cerebral blood flow (1CBF), and the flow in the distal stump of the occluded middle cerebral artery were simultaneously recorded in 28 acute experiments in cats.
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Acute cerebral infarction and changes of regional cerebral blow flow (rCBF) following experimental middle cerebral artery (MCA) occlusion.
TL;DR: Group B appeared to take advantage of diaschisis during the late phase of infarct development, as well as the substantial collateral flow from the surrounding anterior and posterior cerebral artery territories, to explore the correlation among changes of rCBF, neurological deficits, and pathological changes.
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From Krönlein, through madness, to a useful modern surgery: the journey of the transorbital corridor to enter the neurosurgical armamentarium
TL;DR: The progression of the transorbital approach not only reflects psychosocial influences on medical therapy, as well as the competition of surgical pioneers for supremacy, but also describes the diversification of skull base techniques, the impact of microsurgical mastery on circumferential neurosurgical corridors, the influence of technology on modernizing skull base surgery, and the advancing trend of multidisciplinary surgical excellence.
References
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Restoration of Middle Cerebral Artery Flow in Experimental Infarction
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The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
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The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
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Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.