Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
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Evaluation of a GPIIb/IIIa antagonist YM337 in a primate model of middle cerebral artery thrombosis.
Seiji Kaku,Kazuo Umemura,Atsuhiro Mizuno,Shinya Yano,Ken-ichi Suzuki,Tomihisa Kawasaki,Mitsuyoshi Nakashima +6 more
TL;DR: The novel selective GPIIb/IIIa antagonist YM337 was effective in ameliorating the decrease in patency of the middle cerebral artery and reducing the area of cerebral infarction in monkeys.
Journal ArticleDOI
Time dependent changes of striatal interneurons after focal cerebral ischemia in rats.
TL;DR: The present results suggest that GABAergic nNOS-positive interneurons in the striatum after focal cerebral ischemia undergo cellular death in a delayed manner.
Journal ArticleDOI
Cerebral energy metabolism measured in vivo by 31P-NMR in middle cerebral artery occlusion in the cat―relation to severity of stroke
S. Komatsumoto,S. Nioka,Joel H. Greenberg,K. Yoshizaki,V. H. Subramanian,Britton Chance,Martin Reivich +6 more
TL;DR: The results suggest that the dynamic process of pathophysiological changes in an MCA occlusion model in the cat leads to significant differences in cerebral metabolism between animals with mild and severe strokes.
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Reduced Nicotinamide Adenine Dinucleotide Fluorescence and Cortical Blood Flow in Ischemic and Nonischemic Squirrel Monkey Cortex. 1. Animal Preparation, Instrumentation, and Validity of Model
TL;DR: The use of the infrared microscope for semiquantitative measurements of cortical blood flow throughout the duration of these acute studies was investigated and found to be reliable.
Journal ArticleDOI
Preclinical assessment of stem cell therapies for neurological diseases.
Valerie Joers,Marina E. Emborg +1 more
TL;DR: The requirements of stem cell-based therapy for clinical translation, advances in stem cell research toward clinical application for neurological disorders, and different animal models used for analysis of these potential therapies are analyzed.
References
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Journal ArticleDOI
Restoration of Middle Cerebral Artery Flow in Experimental Infarction
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The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
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The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
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Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.