Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
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Book ChapterDOI
Textbook of Stroke Medicine: Neuropathology and pathophysiology of stroke
TL;DR: Changes in large arteries supplying the brain, including the aorta, are mainly caused by atherosclerosis, and small vessels of the brain are affected by hyalinosis and fibrosis; this “small-vessel disease” can cause lacunes and, if widespread, is the substrate for vascular cognitive impairment and vascular dementia.
Journal ArticleDOI
Pentobarbital changes compartmental contribution to cerebral blood flow
TL;DR: A selective shunting of blood flow to the slower areas may explain the lowering of intracranial pressure and protection of the deep white matter observed by many authors who use barbiturates in clinical an experimental situations.
Journal ArticleDOI
Synaptic Alterations in Developing Cortical Infarction: An Experimental Investigation in Monkeys
TL;DR: The edema which developed was morphologically distinct from both “vasogenic” and “cytotoxic” edema in that there was early and progressive enlargement of the extracellular space.
Journal ArticleDOI
Interhemispheric steal: An experimental study
C.A.F. Tulleken,A. Van Dieren +1 more
TL;DR: The results seem to prove the existence of the so-called "interhemispheric steal" syndrome.
Journal ArticleDOI
Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke
TL;DR: In this paper , the authors used clinical study intervention timelines in a nonhuman primate model of transient, 4-hour middle cerebral artery occlusion to investigate a potential cerebroprotective effect of the dual adenosine A1R/A3R agonist AST-004.
References
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Journal ArticleDOI
Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
Journal ArticleDOI
The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
Journal ArticleDOI
Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.