Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
Citations
More filters
Journal ArticleDOI
New Targets of Neuroprotection in Ischemic Stroke
TL;DR: This review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts, and examine more closely how experimental data are presently translated to humans.
Journal ArticleDOI
The role of lysosomes in production of ischemic nerve cell changes.
TL;DR: The lysosomes appeared to be less susceptible to ischemia than the other neuronal components, and the alterations that did develop occurred at a time when cell damage was already severe and probably irreversible.
Journal ArticleDOI
Postischemic therapy with MK-801 (dizocilpine) in a primate model of transient focal brain ischemia.
Roland N. Auer,Stuart G. Coupland,Gregor W. Jason,David P. Archer,Jacqueline Payne,Alan J. Belzberg,Masefumi Ohtaki,Bruce I. Tranmer +7 more
TL;DR: It is concluded that MK-801 given 20 min after the onset of transient ischemia offers no significant neuroprotective effect against either neurobehavioral deficit or ischemic infarction in this model of transient focal ischemies, and that brain activation occurs in primates as it does in rodents.
Journal ArticleDOI
Acute ultrastructural changes in the middle cerebral artery due to the injury and ischemia of surgical clamping.
TL;DR: Ulastructural changes in the zone of clamping of the middle cerebral artery of the squirrel monkey are described after application of a surgical clip to suggest temporary or permanent impairment of neurogenic innervation of the cerebral vessels distal to the trunk of the vessel clipped.
Journal ArticleDOI
Participation of cerebrovascular nerves in generalized sympathetic discharge. Nonspecific release of norepinephrine in the presence or absence of subarachnoid hemorrhage and vasospasm.
TL;DR: It is concluded that the loss of norepinephrine from cerebrovascular nerves is not specifically related to SAH and mechanical stimulation of cerebral vessels, but is instead part of a more generalized adrenergic discharge produced in response to one or more undefined stimuli ("stress") present even in the sham situation.
References
More filters
Journal ArticleDOI
Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
Journal ArticleDOI
The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
Journal ArticleDOI
Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.