Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
Citations
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Selective lenticulostriate occlusion in the primate. A highly focal cerebral ischemia model.
TL;DR: A highly reliable model for the study of focal cerebral ischemia has been developed using a retro-orbital approach to occlude the lateral lenticulostriate arteries of the baboon using selective vessel occlusion.
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FK506 Attenuates Early Ischemic Neuronal Death in a Monkey Model of Stroke
Hiroyuki Takamatsu,Hideo Tsukada,Akihiro Noda,Takeharu Kakiuchi,Shingo Nishiyama,Shintaro Nishimura,Kazuo Umemura +6 more
TL;DR: It is shown that FK506 showed a powerful neuroprotective effect in a nonhuman primate model of stroke and was detected only in areas with >40% CMRO(2) reduction 3 h after reperfusion.
Journal ArticleDOI
Protective effects of methyl prednisolone and dimethyl sulfoxide in experimental middle cerebral artery embolectomy
Ranjit K. Laha,Manuel Dujovny,Pedro J. Barrionuevo,Samuel C. DeCastro,Harold R. Hellstrom,Joseph C. Maroon +5 more
TL;DR: The canine middle cerebral artery was embolized by means of a pliable cylinder, 8 mm long by 1.6 mm in diameter, via the internal carotid artery to treat acute arterial embolism in children and young adults with stroke morbidity and showed no infarction of the brain.
Journal ArticleDOI
Correlation Between Transcranial Doppler Ultrasonography and Regional Cerebral Blood Flow in Experimental Intracranial Hypertension
TL;DR: The critical level of brain circulation can be detected by Doppler sonography, indicating that TCD is available as a tool for the assessment of cerebral circulatory arrest in brain death.
Journal ArticleDOI
Brain Lipid Changes Following Hypoxia
F. M. Yatsu,S. A. Moss +1 more
TL;DR: The lipid alterations indicate a reparative process following a suppression of lipid metabolism during hypoxia, and the pattern of elongation more closely resembled that seen during myelination rather than maturity.
References
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Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
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The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
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Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.