Transorbital Approach to the Middle Cerebral Artery of the Squirrel Monkey: A Technique for Experimental Cerebral Infarction Applicable to Ultrastructural Studies
W. R. Hudgins,Julio H. Garcia +1 more
TLDR
Modifications to a previously devised method for induction of cerebral infarct are herein described and this new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebralinfarctions.Abstract:
An appropriate surgical technique for the production of cerebral infarction must fulfill, among others, the following criteria in order to be suitable for electron microscopy (EM) studies: (1) the method of arterial occlusion should yield a high percentage of infarcts with predictable average size; (2) there must be avoidance of surgical manipulation (i.e., retraction) of the cerebral tissues or exposure of the same to the atmosphere; and (3) the method for occluding the artery must be one that permits fixation by perfusion of the ischemic and nonischemic brain.
Modifications to a previously devised method for induction of cerebral infarct are herein described. This new surgical approach has made it possible to conduct detailed and sequential ultrastructural analysis of experimental cerebral infarctions.read more
Citations
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PET study of changes in local brain hemodynamics and oxygen metabolism after unilateral middle cerebral artery occlusion in baboons.
Sabina Pappatà,M. Fiorelli,Thomas Rommel,Alexander Hartmann,C. Dettmers,Tatsuo Yamaguchi,Hugues Chabriat,Jean-Baptiste Poline,Christian Crouzel,L. Di Giamberardino,Jean-Claude Baron +10 more
TL;DR: The study demonstrates the feasibility of the combined PET-MCAO paradigm in baboons; this experimental approach should be valuable in investigating the pathophysiology and therapy of acute stroke.
Journal ArticleDOI
Differential outcome to middle cerebral artery occlusion in spontaneously hypertensive stroke-prone rats (SHRSP) and Wistar Kyoto (WKY) rats.
P Coyle,P T Jokelainen +1 more
TL;DR: The limited focal lesion observed in normotensive and sham operated rats is primarily due to surgical trauma of exposing the vessel and passing the ligature deep to it, and is the result of an inadequate circulation provided by the dorsal cerebral arterial collaterals.
Journal ArticleDOI
Reduction in brain dopamine following experimental cerebral ischaemia.
TL;DR: The observations reported here show that ligature of the middle cerebral artery in monkeys, or of the common carotid artery in gerbils, causes profound decreases in brain dopamine but not noradrenaline.
Journal ArticleDOI
Dorsal cerebral arterial collaterals of the rat.
Peter Coyle,Pentti T. Jokelainen +1 more
TL;DR: In this article, the anterior cerebral artery (ACA) is joined by interarterial anastomoses to rami of the middle cerebral artery in the normal Wistar rat.
Journal ArticleDOI
Middle cerebral artery occlusion in the young rat.
TL;DR: MCA occlusion beyond the point of origin of the striate branches in the young rat results in neither neurological deficits, dye markings, nor histologic changes in the distal vascular field to indicate an infarct, apparently, the young rodent collateral supply maintains the tissue in a viable state.
References
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Restoration of Middle Cerebral Artery Flow in Experimental Infarction
Journal ArticleDOI
The Cerebral Collateral Circulation: 1. Factors Influencing Collateral Blood Flow
John S. Meyer,D. Denny-Brown +1 more
TL;DR: The present study was undertaken to analyze factors influencing the efficiency of the cerebral collateral circulation as measured by means of the polarographic technic, to clarify the circumstances whereby collateral blood flow fails to prevent infarction, and to determine whether any aspects ofinfarction are reversible.
Experimental cerebral infarction: retro-orbital, extradural approach for occluding the middle cerebral artery.
Thoralf M. Sundt,Arthur G. Waltz +1 more
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The effect of acute hypoxia and hypercapnia on the ultrastructure of the central nervous system
Louis Bakay,J. C. Lee +1 more
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Localized changes in properties of the blood and effects of anticoagulant drugs in experimental cerebral infarction.
TL;DR: Clinical and experimental evidence indicates that after a delay such treatment may result in recanalization of a thrombosed vessel, and this type of treatment improves transient symptoms due to intermittent ischemia, and decreases the occurrence of cerebral embolism andThrombosis but does not alter the course of cerebral infarction once established.