Journal ArticleDOI
Treatment of Lateral Epicondylitis With Platelet-Rich Plasma, Glucocorticoid, or Saline A Randomized, Double-Blind, Placebo-Controlled Trial
Thøger Persson Krogh,Ulrich Fredberg,Kristian Stengaard-Pedersen,Robin Christensen,Robin Christensen,Pia Jensen,Torkell Ellingsen +6 more
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TLDR
Neither injection of PRP nor glucocorticoid was superior to saline with regard to pain reduction in LE at the primary end point at 3 months, and neither had a short-term pain-reducing effect at 1 month in contrast to the other therapies.Abstract:
Background:Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown.Purpose:To examine whether a single injection of platelet-rich plasma (PRP) is more effective than placebo (saline) or glucocorticoid in reducing pain in adults with LE after 3 months.Study Design:Randomized controlled trial; Level of evidence, 1.Methods:A total of 60 patients with chronic LE were randomized (1:1:1) to receive either a blinded injection of PRP, saline, or glucocorticoid. The primary end point was a change in pain using the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire at 3 months. Secondary outcomes were ultrasonographic changes in tendon thickness and color Doppler activity.Results:Pain reduction at 3 months (primary end point) was observed in all 3 groups, with no statistically significant difference between the groups; mean differences were the following: glucocorticoid versus saline: −3.8 (95% CI, −9.9 to 2.4); PRP versus saline: −2.7 (95% ...read more
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Platelet-rich plasma for zone II flexor tendon repair
TL;DR: In contrast to previous studies, PRP did not significantly improve ultimate tensile strength and exhibited trends towards reduced healing, including a significant reduction in cell counts as well as a smaller increase in collagen deposition over time as compared to controls.
Journal ArticleDOI
Number of botulinum toxin injections needed to stop requests for treatment for chronic lateral epicondylar tendinopathy. A 1-year follow-up study.
TL;DR: One or 2 BoNT-A injections has favourable results for chronic epicondylar tendinopathy, and quality of life, and painful and maximal gripping force improved significantly at V1, V2 and V3 as compared with V0, and repercussions on daily and professional activities decreased significantly.
Journal ArticleDOI
The role of regenerative medicine in the treatment of sports injuries.
Gerard A. Malanga,Reina Nakamura +1 more
TL;DR: This article reviews the literature regarding established treatments for sports injuries and more innovative treatments, including platelet-rich plasma and stem cell therapies, known as regenerative medicine.
Journal ArticleDOI
Platelet-rich plasma (PRP) treatment of noninsertional Achilles tendinopathy in a two case series: no significant difference in effect between leukocyte-rich and leukocyte-poor PRP
TL;DR: PRP seems to be a possible treatment for chronic Achilles tendinopathies when all other treatment regimens have failed, with a reasonably high probability of reaching MCIC.
Journal ArticleDOI
Long-term follow-up of platelet-rich plasma injections for refractory lateral epicondylitis.
TL;DR: Platelet-rich plasma is successful in treating refractory LE in most patients and avoiding surgery and should be considered for long-term use, according to doctors and patients.
References
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Statistics notes: Analysing controlled trials with baseline and follow up measurements.
TL;DR: In many randomised trials researchers measure a continuous variable at baseline and again as an outcome assessed at follow up to see whether a treatment can reduce pre-existing levels of pain, anxiety, hypertension, and the like.
Journal Article
Musculoskeletal ultrasound including definitions for ultrasonographic pathology
Richard J. Wakefield,Peter V. Balint,Marcin Szkudlarek,Emilio Filippucci,Marina Backhaus,Maria Antonietta D'Agostino,Esperanza Naredo Sanchez,Annamaria Iagnocco,Wolfgang A. Schmidt,George A W Bruyn,David Kane,Philip O'Connor,Bernhard Manger,Fred Joshua,Juhani M. Koski,Walter Grassi,Marissa Lassere,Nanno Swen,Franz Kainberger,Andrea Klauser,Mikkel Østergaard,Andrew K. Brown,Klaus P Machold,Philip G. Conaghan +23 more
TL;DR: The first report from the OMERACT ultrasound special interest group is presented, which has compared US against the criteria of the O MERACT filter, and for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis.
Journal ArticleDOI
Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing
TL;DR: A variety of potentially therapeutic growth factors were detected and released from the platelets in significant levels in platelet-rich plasma preparations and may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications.
Journal ArticleDOI
Platelet-Rich Plasma From Basic Science to Clinical Applications
TL;DR: This study reviews and evaluates the human studies that have been published in the orthopaedic surgery and sports medicine literature and the regulation of PRP by antidoping agencies is discussed.
Journal ArticleDOI
The Roles of Growth Factors in Tendon and Ligament Healing
TL;DR: This review covers some of the recent investigations into the roles of five growth factors whose activities have been best characterised during tendon healing: insulin-like growth factor-I (IGF-I), transforming growth factor β (TGFβ), vascular endothelial growthFactor (VEGF), platelet-derived growth factor (PDGF), and basic fibroblast growth factor ($FGF).