Journal ArticleDOI
Treatment of Lateral Epicondylitis With Platelet-Rich Plasma, Glucocorticoid, or Saline A Randomized, Double-Blind, Placebo-Controlled Trial
Thøger Persson Krogh,Ulrich Fredberg,Kristian Stengaard-Pedersen,Robin Christensen,Robin Christensen,Pia Jensen,Torkell Ellingsen +6 more
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TLDR
Neither injection of PRP nor glucocorticoid was superior to saline with regard to pain reduction in LE at the primary end point at 3 months, and neither had a short-term pain-reducing effect at 1 month in contrast to the other therapies.Abstract:
Background:Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown.Purpose:To examine whether a single injection of platelet-rich plasma (PRP) is more effective than placebo (saline) or glucocorticoid in reducing pain in adults with LE after 3 months.Study Design:Randomized controlled trial; Level of evidence, 1.Methods:A total of 60 patients with chronic LE were randomized (1:1:1) to receive either a blinded injection of PRP, saline, or glucocorticoid. The primary end point was a change in pain using the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire at 3 months. Secondary outcomes were ultrasonographic changes in tendon thickness and color Doppler activity.Results:Pain reduction at 3 months (primary end point) was observed in all 3 groups, with no statistically significant difference between the groups; mean differences were the following: glucocorticoid versus saline: −3.8 (95% CI, −9.9 to 2.4); PRP versus saline: −2.7 (95% ...read more
Citations
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Journal ArticleDOI
The Role of Elbow Tender Point Examination in the Diagnosis of Lateral Epicondylitis.
Sarang K Yoon,Matthew S. Thiese,Ulrike Ott,Jay Kapellusch,Andrew Merryweather,Eric M. Wood,Brenden Ronna,James A. Foster,David L. Drury,Kurt T. Hegmann +9 more
TL;DR: The prevalence of lateral epicondylitis differs markedly based on case definition used, ranging more than two-fold.
Book ChapterDOI
Sacroiliac Joint Injections for the Treatment of Pain in the Rehabilitation Patient
TL;DR: The chapter discusses the anatomy, biomechanics, pathophysiology, diagnosis, and treatment of sacroiliac joint dysfunction (SIJD), with a special focus on the interventional aspect of pain management.
Book ChapterDOI
Office-Based Orthobiologic Procedures for Tendons
TL;DR: There has been a growing interest in the use of office-based orthobiologics, which are defined as use of biological tissues to optimize musculoskeletal/orthopedic injuries, for treatment of tendons for four reasons.
Journal ArticleDOI
Traitement par PRP, mise au point (septembre 2014). 2e partie : les lésions tendineuses
B. Eichene,M. Bouvard +1 more
TL;DR: Tant qu’un consensus sur les methodes de preparation des PRP, leur concentration, leer activation and leur contenu ne sera etabli, il sera difficile de comparer des etudes, meme de haut niveau de preuve, et d’affirmer les benefices des PRp sur the reparation du tissu tendineux.
Journal ArticleDOI
Clinical efficacy of local injection therapies for lateral epicondylitis: A systematic review and network meta-analysis
Mehdi Tavassoli,Rahmatollah Jokar,Mohammad Zamani,Soraya Khafri,Seyed Mokhtar Esmaeilnezhad Ganji +4 more
TL;DR: CSs and BT are efficient in improving clinical outcomes of lateral epicondylitis in the short term and the efficacy of CSs seems to be greater than BT, while AB and PRP were not significantly more efficient than placebo in any times of follow-up.
References
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Journal ArticleDOI
Statistics notes: Analysing controlled trials with baseline and follow up measurements.
TL;DR: In many randomised trials researchers measure a continuous variable at baseline and again as an outcome assessed at follow up to see whether a treatment can reduce pre-existing levels of pain, anxiety, hypertension, and the like.
Journal Article
Musculoskeletal ultrasound including definitions for ultrasonographic pathology
Richard J. Wakefield,Peter V. Balint,Marcin Szkudlarek,Emilio Filippucci,Marina Backhaus,Maria Antonietta D'Agostino,Esperanza Naredo Sanchez,Annamaria Iagnocco,Wolfgang A. Schmidt,George A W Bruyn,David Kane,Philip O'Connor,Bernhard Manger,Fred Joshua,Juhani M. Koski,Walter Grassi,Marissa Lassere,Nanno Swen,Franz Kainberger,Andrea Klauser,Mikkel Østergaard,Andrew K. Brown,Klaus P Machold,Philip G. Conaghan +23 more
TL;DR: The first report from the OMERACT ultrasound special interest group is presented, which has compared US against the criteria of the O MERACT filter, and for the first time are consensus US definitions for common pathological lesions seen in patients with inflammatory arthritis.
Journal ArticleDOI
Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing
TL;DR: A variety of potentially therapeutic growth factors were detected and released from the platelets in significant levels in platelet-rich plasma preparations and may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications.
Journal ArticleDOI
Platelet-Rich Plasma From Basic Science to Clinical Applications
TL;DR: This study reviews and evaluates the human studies that have been published in the orthopaedic surgery and sports medicine literature and the regulation of PRP by antidoping agencies is discussed.
Journal ArticleDOI
The Roles of Growth Factors in Tendon and Ligament Healing
TL;DR: This review covers some of the recent investigations into the roles of five growth factors whose activities have been best characterised during tendon healing: insulin-like growth factor-I (IGF-I), transforming growth factor β (TGFβ), vascular endothelial growthFactor (VEGF), platelet-derived growth factor (PDGF), and basic fibroblast growth factor ($FGF).