Journal ArticleDOI
Treatment of REM sleep behavior disorder with donepezil: a report of three cases.
John M. Ringman,J.H. Simmons +1 more
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Three patients with REM behavior disorder whose nocturnal symptoms were markedly improved by treatment with the acetylcholinesterase inhibitor donepezil are reported.Abstract:
Three patients with REM behavior disorder whose nocturnal symptoms were markedly improved by treatment with the acetylcholinesterase inhibitor donepezil are reported. Donepezil may have a role in the treatment of REM behavior disorder, possibly through its actions on cholinergic pathways in the brainstem.read more
Citations
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Journal ArticleDOI
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
B. F. Boeve,M. H. Silber,Clifford B. Saper,Tanis J. Ferman,Dennis W. Dickson,Joseph E. Parisi,Eduardo E. Benarroch,J. E. Ahlskog,Glenn E. Smith,R. C. Caselli,M. Tippman-Peikert,E. J. Olson,Siong-Chi Lin,T. Young,Z. Wszolek,C. H. Schenck,M. W. Mahowald,Pablo R. Castillo,K. Del Tredici,Heiko Braak +19 more
TL;DR: The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented.
Journal ArticleDOI
REM sleep behavior disorder
TL;DR: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep as discussed by the authors.
Journal ArticleDOI
Non-motor Symptoms of Parkinson's Disease
TL;DR: The characteristics, pathophysiology, epidemiology, and management of non-motor symptoms of Parkinson's disease including cognitive declines, psychiatric disturbances, and autonomic failures are discussed.
Journal ArticleDOI
Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD)
R. Nisha Aurora,Rochelle S. Zak,Rama Maganti,Sanford Auerbach,Kenneth R. Casey,Susmita Chowdhuri,Anoop Karippot,Kannan Ramar,David A. Kristo,Timothy I. Morgenthaler +9 more
TL;DR: Modifying the sleep environment is recommended for the treatment of patients with RBD who have sleep-related injury and the use of Clonazepam should be used with caution in patients with dementia, gait disorders, or concomitant OSA.
Journal ArticleDOI
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
TL;DR: Melatonin can be considered as a possible sole or add-on therapy in select patients with RBD and persistent benefit with melatonin beyond 1 year of therapy occurred in most but not all patients.
References
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Journal ArticleDOI
REM sleep behavior disorder and degenerative dementia: An association likely reflecting Lewy body disease
Bradley F. Boeve,Michael H. Silber,Tanis J. Ferman,Emre Kokmen,Glenn E. Smith,Robert J. Ivnik,Joseph E. Parisi,Eric J. Olson,R. C. Petersen +8 more
TL;DR: A group of predominantly male patients with a characteristic association of RBD and degenerative dementia is reported, and it is hypothesized that the underlying pathology in these patients is DLB.
Journal ArticleDOI
REM sleep parasomnias.
TL;DR: The three states of mammalian being--wakefulness, REM sleep, and NREM sleep--are not mutually exclusive and may occur simultaneously, oscillate rapidly, or appear in dissociated or incomplete form to produce primary sleep parasomnias.
Journal ArticleDOI
Contributions of the Pedunculopontine Region to Normal and Altered REM Sleep
TL;DR: Evidence is reviewed that changes in the quality, timing, and quantity of REM sleep that characterize narcolepsy, REM sleep behavior disorder, and neurodegenerative and affective disorders (depression and schizophrenia) reflect 1) changes in responsiveness of cells in the PPN region governed by these afferents; or 2) increase or decrease in PPN cell number.
Book ChapterDOI
Chapter 5: The organization of central cholinergic systems and their functional importance in sleep-waking states
TL;DR: By interaction with other cell groups, including monoaminergic and GABAergic neurons, and by differential modes of firing, the cholinergic neurons may shape the responsiveness and activity of the reticular core and thalamo-cortical systems across the sleep-waking cycle.
Journal ArticleDOI
Rapid eye movement sleep behavior disorder preceding Parkinson's disease with therapeutic response to levodopa
TL;DR: Three patients are presented here whose RBD preceded the onset of PD by several years, and both the symptoms of PD and RBD improved with levodopa treatment, and it remains to be seen whetherlevodopa can be an alternative to clonazepam in idiopathic RBD without PD.