REM sleep behavior disorder
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TLDR
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep as discussed by the authors.Abstract:
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. The polysomnographic features of RBD include increased electromyographic tone +/- dream enactment behavior during REM sleep. Management with counseling and pharmacologic measures is usually straightforward and effective. In this review, the terminology, clinical and polysomnographic features, demographic and epidemiologic features, diagnostic criteria, differential diagnosis, and management strategies are discussed. Recent data on the suspected pathophysiologic mechanisms of RBD are also reviewed. The literature and our institutional experience on RBD are next discussed, with an emphasis on the RBD-neurodegenerative disease association and particularly the RBD-synucleinopathy association. Several issues relating to evolving concepts, controversies, and future directions are then reviewed, with an emphasis on idiopathic RBD representing an early feature of a neurodegenerative disease and particularly an evolving synucleinopathy. Planning for future therapies that impact patients with idiopathic RBD is reviewed in detail.read more
Citations
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Book
Dementia With Lewy Bodies
TL;DR: The current state of scientific knowledge on DLB is reviewed to show that treatment with cholinesterase inhibitors is well tolerated by most patients and substantially improves cognitive and neuropsychiatric symptoms.
Journal ArticleDOI
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
TL;DR: The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iR BD, with the mean interval being 14 years while the range extended to 29 years.
Journal ArticleDOI
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study
Alex Iranzo,Eduard Tolosa,Ellen Gelpi,José Luis Molinuevo,Francesc Valldeoriola,Mónica Serradell,Raquel Sánchez-Valle,Isabel Vilaseca,Francisco Lomeña,Dolores Vilas,Albert Lladó,Carles Gaig,Joan Santamaria +12 more
TL;DR: These findings indicate that in most patients diagnosed with IRBD this parasomnia represents the prodromal phase of a Lewy body disorder, and IRBD is a candidate for the study of early events and progression of this prodromic phase, and to test disease-modifying strategies to slow or stop the neurodegenerative process.
Journal ArticleDOI
Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients.
Alex Iranzo,Ana Fernández-Arcos,Eduard Tolosa,Mónica Serradell,José Luis Molinuevo,Francesc Valldeoriola,Ellen Gelpi,Isabel Vilaseca,Raquel Sánchez-Valle,Albert Lladó,Carles Gaig,Joan Santamaria +11 more
TL;DR: In a large IRBD cohort diagnosed in a tertiary referal sleep center, prolonged follow-up indicated that the majority of patients are eventually diagnosed with the synucleinopathies PD, DLB and less frequently MSA.
Journal ArticleDOI
Lewy body dementias
Zuzana Walker,Zuzana Walker,Katherine L. Possin,Bradley F Boeve,Dag Aarsland,Dag Aarsland,Dag Aarsland +6 more
TL;DR: The most pertinent progress from the past 10 years is summarized, outlining some of the challenges for the future, which will require refinement of diagnosis and clarification of the pathogenesis, leading to disease-modifying treatments.
References
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