Journal ArticleDOI
Tunicamycin--an inhibitor of yeast glycoprotein synthesis.
S.-C. Kuo,J.O. Lampen +1 more
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TLDR
In yeast tunicamycin acts primarily as an inhibitor of glycoprotein synthesis and not of general glucosamine metabolism, and incorporation of 3H-glucosamine into trichloroacetic acid-insoluble products was only partially reduced.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1974-05-07. It has received 274 citations till now. The article focuses on the topics: Tunicamycin & Acid phosphatase.read more
Citations
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Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes.
Jan S. Tkacz,J. Oliver Lampen +1 more
TL;DR: Tunicamycin inhibited the production of the [3H]G1cNAc-lipid but did not affect the synthesis of the 14C-mannolipid, which accounts for the effect of the antibiotic upon glycoprotein formation in vivo.
Journal ArticleDOI
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
Ainslie B. Parsons,Renee L. Brost,Huiming Ding,Zhijian Li,Chaoying Zhang,Bilal N. Sheikh,Grant W. Brown,Patricia M. Kane,Timothy P. Hughes,Charles Boone +9 more
TL;DR: By filtering chemical-genetic profiles for the multidrug-resistant genes and then clustering the compound-specific profiles with a compendium of large-scale genetic interaction profiles, this method provides a powerful means for inferring mechanism of action.
Journal ArticleDOI
Genomic profiling of drug sensitivities via induced haploinsufficiency.
Guri Giaever,Daniel D. Shoemaker,Ted Jones,Hong Liang,Elizabeth A. Winzeler,Anna Astromoff,Ronald W. Davis +6 more
TL;DR: The discovery that both drug target and hypersensitive loci exhibit drug-induced haploinsufficiency may have important consequences in pharmacogenomics and variable drug toxicity observed in human populations.
Journal ArticleDOI
Carbohydrate moieties of glycoproteins a re-evaluation of their function
TL;DR: It is proposed that the carbohydrate acts as a chemical ‘tag’ which, upon interaction with a specific intracellular membrane receptor, directs glycoproteins to specific cellular organelles following synthesis on the rough endoplasmic reticulum.
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Role of carbohydrates in protein secretion and turnover: Effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts
TL;DR: In this paper, the role of glycosylation in the biosynthesis, processing and turnover of CSP, the major cell surface glycoprotein of chick embryo fibroblasts (CEF), was investigated.
References
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Journal ArticleDOI
Tunicamycin, a new antibiotic. i
TL;DR: Tunicamycin is a new antiviral antibiotic produced by Streptomyces lysosuperificus, nov. sp.
Journal ArticleDOI
Purification of the Internal Invertase of Yeast
S Gascón,J O Lampen +1 more
TL;DR: A comparative study of the distribution of invertase isozymes in two stains of yeast and, after the selection of the best conditions and source, the purification of the internal or small enzyme is presented.
Journal ArticleDOI
The purification and properties of an α-glucoside of Saccharomyces italicus Y1225
TL;DR: The purification and properties of α-glucosidase from Saccharomyces italicus Y1225 have been studied and it is suggested that substrate hydrolysis involves an ionizable group of pKa 6.6–6.8.
Journal ArticleDOI
Effect of tunicamycin on the synthesis of macromolecules in cultures of chick embryo fibroblasts infected with newcastle disease virus
Akira Takatsuki,Gakuzo Tamura +1 more
TL;DR: The effect of tunicamycin on the synthesis of macromolecules in cultures of chick embryo fibroblasts was investigated by measuring the incorporation of radioactive percursors into acid-insoluble product after infection or mockinfection with Newcastle disease virus.
Journal ArticleDOI
Lysis of viable yeast cells by enzymes of Arthrobacter luteus
TL;DR: In this article, the authors identified the strain (B 111-1) showing the highest lytic activity as Arthrobacter luteus, and the optimum pH for lysis of viable yeast cells was 7.0-8.0.
Related Papers (5)
Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes.
Jan S. Tkacz,J. Oliver Lampen +1 more
The specific site of tunicamycin inhibition in the formation of dolichol-bound N-acetylglucosamine derivatives
Ludwig Lehle,Widmar Tanner +1 more