Journal ArticleDOI
UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation
TLDR
Assessment of risk by a combination of maternal age and fetal nuchal-translucency thickness, measured by ultrasonography at 10-14 weeks of gestation, finds that selection of the high-risk group for invasive testing by this method allows the detection of about 80% of affected pregnancies.About:
This article is published in The Lancet.The article was published on 1998-08-01. It has received 1532 citations till now. The article focuses on the topics: Trisomy & Prenatal diagnosis.read more
Citations
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Journal ArticleDOI
Helping Doctors and Patients Make Sense of Health Statistics
TL;DR: In this paper, the authors discuss the importance of teaching statistical thinking and transparent representations in primary and secondary education as well as in medical school, and recommend using frequency statements instead of single-event probabilities, absolute risks instead of relative risks, mortality rates instead of survival rates, and natural frequencies instead of conditional probabilities.
Journal ArticleDOI
First-trimester or second-trimester screening, or both, for down's syndrome
Fergal D. Malone,Fergal D. Malone,Fergal D. Malone,Jacob A. Canick,Robert H. Ball,David A. Nyberg,Christine H. Comstock,Radek Bukowski,Richard L. Berkowitz,Susan J. Gross,Lorraine Dugoff,Sabrina D. Craigo,Ilan E. Timor-Tritsch,Stephen R. Carr,Honor M. Wolfe,Kimberly A. Dukes,Diana W. Bianchi,Alicja R. Rudnicka,A. K. Hackshaw,A. K. Hackshaw,Geralyn Lambert-Messerlian,Nicholas J. Wald,Mary E. D'Alton +22 more
TL;DR: First-trimester combined screening at 11 weeks of gestation is better than secondtrimester quadruple screening but at 13 weeks has results similar to second-tr pregnancy quadruple screened, except for the comparison between serum integrated screening and combined screening.
Journal ArticleDOI
ACOG practice bulletin: Clinical management guidelines for obstetrician-gynecologists
Helping doctors and patients make sense of health statistics: towards an evidence-based society
TL;DR: Evidence is provided that statistical illiteracy is common to patients, journalists, and physicians and that information pamphlets, Web sites, leaflets distributed by the pharmaceutical industry, and even medical journals often report evidence in nontransparent forms that suggest big benefits of featured interventions and small harms.
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Diagnosis and Treatment of Fetal Cardiac Disease A Scientific Statement From the American Heart Association
Mary T. Donofrio,Anita J. Moon-Grady,Lisa K. Hornberger,Joshua A. Copel,Mark Sklansky,Alfred Abuhamad,Bettina F. Cuneo,James C. Huhta,Richard A. Jonas,Anita Krishnan,Stephanie Lacey,Wesley Lee,Erik C. Michelfelder,Gwen R. Rempel,Norman H. Silverman,Thomas L. Spray,Janette F. Strasburger,Wayne Tworetzky,Jack Rychik +18 more
TL;DR: This statement highlights what is currently known and recommended on the basis of evidence and experience in the rapidly advancing and highly specialized field of fetal cardiac care.
References
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Journal ArticleDOI
Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy.
TL;DR: Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
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Maternal serum screening for Down's syndrome in early pregnancy.
Nicholas J. Wald,HowardS. Cuckle,J. W. Densem,K. Nanchahal,Patrick Royston,Tim Chard,James E. Haddow,G J Knight,Glenn E. Palomaki,Jacob A. Canick +9 more
TL;DR: The new screening method would detect over 60% of affected pregnancies, more than double that achievable with the same amniocentesis rate in existing programmes, and could reduce the number of children born with Down's syndrome in the United Kingdom from about 900 a year to about 350 a year.
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The hidden mortality of monochorionic twin pregnancies.
TL;DR: In an ultrasound screening study for measurement of fetal nuchal translucency thickness there were 102 monochorionic and 365 dichorionic twin pregnancies and the proportion of pregnancies with a birthweight discordancy of more than 25% was similar in the two groups.
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Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation.
Pranav Pandya,Roslainde J. M. Snijders,Sarah P. Johnson,Maria de Lourdes Brizot,Kypros H. Nicolaids +4 more
TL;DR: Screening for fetal trisomy 21 can be carried out effectively during the first trimester of pregnancy using a new method of screening which involves assessment of individual risk based on the combination of fetal nuchal translucency, crown rump length and maternal age.
Journal ArticleDOI
The lambda sign at 10–14 weeks of gestation as a predictor of chorionicity in twin pregnancies
TL;DR: High reliability of ultrasound examination at 10–14 weeks of gestation in determining chorionicity in twin pregnancies demonstrates the high reliability of ultrasounds in Obstetrics and Gynecology.