Journal ArticleDOI
Understanding clinical and immunological features associated with Pseudomonas and Staphylococcus keratitis.
TLDR
The role of macrophage inflammatory protein-2 (MIP-2) and intercellular adhesion molecule (ICAM-1) in neutrophil recruitment based on both in-vivo scratch models of bacterial keratitis and bacterial challenged in cell culture models is discussed.About:
This article is published in Contact Lens and Anterior Eye.The article was published on 2021-02-01. It has received 16 citations till now. The article focuses on the topics: Contact lens & Keratitis.read more
Citations
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Journal Article
Incidence of keratitis of varying severity among contact lens wearers
Philip B. Morgan,Nathan Efron,Elizabeth A. Hill,Mathew K. Raynor,Mark A. Whiting,Andrew B. Tullo +5 more
TL;DR: In this article, a clinical severity matrix was used to differentiate between non-severe and severe keratitis (SK) among wearers of current generation contact lenses, based on the severity of signs and symptoms.
Journal Article
Inhibition by the Antimicrobial Peptide LL37 of Lipopolysaccharide-Induced Innate Immune Responses in Human Corneal FibroblastsLPS-Induced Immune Response Inhibition by LL37
TL;DR: The inhibition of LPS-induced cytokine and adhesion molecule expression in human corneal fibroblasts by LL37 suggests that this peptide might promote the resolution of cornean inflammation associated with bacterial infection.
Posted ContentDOI
Determination of probability of causative pathogen in infectious keratitis using deep learning algorithm of slit-lamp images.
Ayumi Koyama,Dai Miyazaki,Yuji Nakagawa,Yuji Ayatsuka,Hitomi Miyake,Fumie Ehara,Shin-ichi Sasaki,Yumiko Shimizu,Yoshitsugu Inoue +8 more
TL;DR: In this paper, a hybrid deep learning-based algorithm was used for computer-assisted diagnosis of infectious keratitis, which achieved a high overall accuracy of diagnosis, e.g., the accuracy/area under the curve for acanthamoeba was 97.9%/0.995, bacteria was 90.7% /0.963, fungi was 95.0%/ 0.975, and HSV was 92.3% / 0.946.
Journal ArticleDOI
What Is New in the Anti–Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?
Sophie Bleves,Gwénaëlle Mainsant +1 more
TL;DR: In this article , the authors focus on new solutions for P. aeruginosa infections that are in active clinical development, i.e., currently being tested in humans and may be approved for patients in the coming years.
Journal ArticleDOI
Vision redemption: Self-reporting AIEgens for combined treatment of bacterial keratitis.
Chen Peng,Chen Peng,Wenjie Sun,Chengcheng Zhou,Sujing Qiang,Meijuan Jiang,Jacky Wing Yip Lam,Zheng Zhao,Ryan T. K. Kwok,Wenting Cai,Ben Zhong Tang,Ben Zhong Tang +11 more
TL;DR: In this article, a cationic diphenyl luminogen with aggregation-induced emission called IQ-Cm containing isoquinolinium and coumarin units for theranostic study of BK is reported.
References
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Journal ArticleDOI
Toll-like receptors: critical proteins linking innate and acquired immunity.
TL;DR: Evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses.
Journal ArticleDOI
Neutrophil extracellular traps in immunity and disease
TL;DR: The identification of molecules that modulate the release of NETs has helped to refine the view of the role of neutrophils in immune protection, inflammatory and autoimmune diseases and cancer.
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Corneal blindness: a global perspective
TL;DR: Diseases affecting the cornea are a major cause of blindness worldwide, second only to cataract in overall importance and public health prevention programmes are the most cost-effective means of decreasing the global burden.
Journal ArticleDOI
Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases
TL;DR: In this article, a retrospective analysis of the hospital records of patients presenting with bacterial keratitis and treated at the Quinze-Vingts National Center of Ophthalmology, Paris, France, was performed during a 20 month period.
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A guide to chemokines and their receptors.
TL;DR: This guide gives a broad overview of the chemokines and chemokine receptor families; summarizes the complex physical interactions that occur in theChemokine network; and, using specific examples, discusses general principles of Chemokine function, focusing particularly on their ability to direct leukocyte migration.
Related Papers (5)
Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice
Analysis of Inpatients with Contact Lens Related Bacterial Keratitis: Causative Microorganisms, Clinical Aspects, and Prognostic Factors.
Chan Ho Cho,Sang Bumm Lee +1 more