Open AccessJournal Article
Use of synthetic peptides in primates to induce high-titered neutralizing antibodies and MHC class I-restricted cytotoxic T cells against acquired immunodeficiency syndrome retroviruses: an HLA-based vaccine strategy.
Barton F. Haynes,Y. Yasutomi,José V. Torres,M. B. Gardner,A. J. Langlios,Dani P. Bolognesi,T J Matthews,Richard M. Scearce,D M Jones,M. A. Moody +9 more
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This article is published in Transactions of the Association of American Physicians.The article was published on 1993-01-01 and is currently open access. It has received 9 citations till now. The article focuses on the topics: MHC class I & Cytotoxic T cell.read more
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HIV vaccines: where we are and where we are going
TL;DR: In view of the complex biology of HIV-host interactions, the most fruitful avenue may be development of multivalent HIV immunogens tailored to HIV isolates in specific geographical locations.
Journal ArticleDOI
Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.
Barney S. Graham,M. Juliana McElrath,Michael C. Keefer,Kyle Rybczyk,David Berger,Kent J. Weinhold,Janet Ottinger,Guido Ferarri,David C. Montefiori,Don Stablein,Carol Smith,Richard Ginsberg,John H. Eldridge,Ann Duerr,Pat Fast,Barton F. Haynes +15 more
TL;DR: The severity of local responses related to the formulation of these four peptides in IFA is clinically unacceptable for continued development and careful, incremental clinical evaluation is warranted to minimize the risk of adverse events.
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Identification of most frequent HLA class I antigen specificities in Botswana: relevance for HIV vaccine design.
Vladimir Novitsky,Pedro O. Flores-Villanueva,Pride Chigwedere,S. Gaolekwe,Hermann Bussman,Gaseene Sebetso,Richard Marlink,Edmond J. Yunis,Max Essex +8 more
TL;DR: The findings suggest that the design of an HLA-based HIV vaccine that includes multiple CTL epitopes restricted by identified common HLA class I specificities might target up to 97.5% of the population in Botswana.
Journal ArticleDOI
Mass Spectrometry and Peptide-based Vaccine Development
TL;DR: Dramatic improvements have been made in mass spectrometer performance for peptide sequencing in terms of increased sensitivity, the ability to rapidly obtain data‐directed tandem mass spectra, and the accuracy of mass measurement.
Journal ArticleDOI
Human leukocyte antigen polymorphisms: variable humoral immune responses to viral vaccines.
TL;DR: Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles, which explain why vaccine-induced humoral immune responses vary among individuals and between populations, and may also hold the key to the development of future generations of vaccines.