Vascular patterning in human heterotopic ossification.
Margaret Cocks,Aditya Mohan,Carolyn A. Meyers,Catherine Ding,Benjamin Levi,Edward F. McCarthy,Aaron W. James +6 more
TLDR
Human HO demonstrates a time- and space-dependent pattern of vascularization suggesting a coupled pathophysiologic process involving the coordinate processes of osteogenesis and angiogenesis, and whether anti-angiogenic therapies are a conceivable future therapy for this common condition.About:
This article is published in Human Pathology.The article was published on 2017-05-01 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Heterotopic ossification & Myositis ossificans.read more
Citations
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Journal ArticleDOI
Heterotopic Ossification: A Comprehensive Review.
Carolyn A. Meyers,Jeffrey Lisiecki,Sarah Miller,Adam S. Levin,Laura M. Fayad,Catherine Ding,Takashi Sono,Edward F. McCarthy,Benjamin Levi,Aaron W. James +9 more
TL;DR: This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms, as well as current concepts regarding the mechanistic bases for HO.
Journal ArticleDOI
Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification.
Charles Hwang,Simone Marini,Amanda K. Huber,David M. Stepien,Michael Sorkin,Shawn Loder,Chase A. Pagani,John Li,Noelle D. Visser,Kaetlin Vasquez,Mohamed A. Garada,Shuli Li,Jiajia Xu,Ching Yun Hsu,Paul B. Yu,Aaron W. James,Yuji Mishina,Shailesh Agarwal,Jun Li,Benjamin Levi +19 more
TL;DR: It is demonstrated that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.
Journal ArticleDOI
Macrophages in heterotopic ossification: from mechanisms to therapy
TL;DR: In this article, the role of macrophages in HO is discussed and a review of the molecular mechanisms through which macrophage participate in MSC osteogenic differentiation, angiogenesis, and the hypoxic microenvironment.
Journal ArticleDOI
Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis.
TL;DR: In this article, a review of the role of endocrine regulatory loops between bone and the vasculature in angiogenesis and osteogenesis is presented, and a deeper understanding of the cellular and molecular regulation of these processes may offer an opportunity to identify new therapeutic targets.
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Effects of hydrogen peroxide on biological characteristics and osteoinductivity of decellularized and demineralized bone matrices.
Quan Qing,Yan-Jing Zhang,Jie-Liang Yang,Liang-Ju Ning,Ya-Jing Zhang,Yan-Lin Jiang,Yi Zhang,Jing-Cong Luo,Ting-Wu Qin +8 more
TL;DR: Findings suggest that the BMP-2 in DCDBMs could be the target of H2 O2, which could be expected to be used as a promising scaffold for tissue engineering and significantly reduced osteoinductivity in HPTBMs.
References
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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
Eileen M. Shore,Meiqi Xu,George J. Feldman,David A. Fenstermacher,Tae Joon Cho,In Ho Choi,J. Michael Connor,Patricia Delai,David L. Glaser,Martine Lemerrer,Rolf Morhart,John G. Rogers,Roger Smith,James T. Triffitt,J. Andoni Urtizberea,Michael Zasloff,Matthew A. Brown,Matthew A. Brown,Frederick S. Kaplan +18 more
TL;DR: Protein modeling predicts destabilization of the GS domain, consistent with constitutive activation of ACVR1 as the underlying cause of the ectopic chondrogenesis, osteogenesis and joint fusions seen in FOP.
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The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
Ying Wang,Chao Wan,Lianfu Deng,Ximeng Liu,Xuemei Cao,Shawn R. Gilbert,Mary L. Bouxsein,Marie Claude Faugere,Robert E. Guldberg,Louis C. Gerstenfeld,Volker H. Haase,Randall S. Johnson,Ernestina Schipani,Thomas L. Clemens,Thomas L. Clemens +14 more
TL;DR: It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone.
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Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration
Chao Wan,Shawn R. Gilbert,Ying Wang,Xuemei Cao,Xing Shen,Girish Ramaswamy,Kimberly A. Jacobsen,Zainab S Al-Aql,Alan W. Eberhardt,Louis C. Gerstenfeld,Thomas A. Einhorn,Lianfu Deng,Thomas L. Clemens,Thomas L. Clemens +13 more
TL;DR: The HIF-1α pathway is identified as a critical mediator of neoangiogenesis required for skeletal regeneration and the application of HIF activators as therapies to improve bone healing is suggested.
Journal ArticleDOI
Heterotopic Ossification: Basic-Science Principles and Clinical Correlates.
Kavitha Ranganathan,Shawn Loder,Shailesh Agarwal,Victor W. Wong,Jonathan A. Forsberg,Thomas A. Davis,Stewart C. Wang,Aaron W. James,Benjamin Levi +8 more
TL;DR: Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury.
Journal ArticleDOI
Heterotopic ossification following traumatic brain injury and spinal cord injury.
TL;DR: Heterotopic ossification can result in a variety of complications, including nerve impingement, joint ankylosis, complex regional pain syndrome, osteoporosis, and softtissue infection, which can greatly limit activities of daily living.