Journal ArticleDOI
Vasodilator profile of synthetic atrial natriuretic factor
TLDR
This first demonstration of the vascular activity of synthetic ANF depicts this substance as a nonselective vasodilator of agonist-induced contractions and suggests a common mechanism of action with sodium nitroprusside.About:
This article is published in European Journal of Pharmacology.The article was published on 1984-06-15. It has received 208 citations till now. The article focuses on the topics: Hydralazine & Angiotensin II.read more
Citations
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Journal ArticleDOI
The Heart and the Atrial Natriuretic Factor
Marc Cantin,Jacques Genest +1 more
TL;DR: The search for natriuretic hormones or factors by studies of negative pressure breathing, atrial distension experiments, head-out water immersion, expansion of blood volume, Na+/K+-ATPase inhibitors and parabiosis experiments in Dahl rats has led to the finding that the atria are a peptide-secreting endocrine gland.
Journal ArticleDOI
Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers
TL;DR: ANP appears to be a circulating hormone in man, at least in severe CHF and supraventricular tachycardia, and plasma ANP levels returned to baseline within 15 min of stopping the infusion.
Journal ArticleDOI
Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function.
Y. Saito,Koichi Nakao,Kazunobu Nishimura,Akira Sugawara,Ken Okumura,Kenji Obata,Ryuji Sonoda,Toshihiko Ban,Hirofumi Yasue,Hiroo Imura +9 more
TL;DR: The findings indicate that the ANP infusion improves left ventricular function in patients with CHF, and suggest that this improvement results mainly from the vasodilating activity of ANP.
Journal ArticleDOI
Cyclic GMP and mechanisms of vasodilation
TL;DR: This review is the result of a widening interest in the role of cGMP in vascular smooth muscle function and now appreciate the fact that cG MP plays a key role in regulating vascular, and probably non-vascular, smooth muscle contractile activity.
Journal ArticleDOI
Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.
TL;DR: The physiology of VGCCs, voltage-gated K+ (KV) channels, large-conductance Ca2+-activated K+ and BKCa channels, strong-inward-rectifier K-IR channels, ATP-sensitive K+ channels, ryanodine receptors (RyRs), inositol 1,4,5-trisphosphate receptors (IP3Rs), and a variety of transient receptor potential (TRP) channels are reviewed.
References
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Journal ArticleDOI
A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
A. J. De Bold,A. J. De Bold,H.B. Borenstein,H.B. Borenstein,A. T. Veress,A. T. Veress,H. Sonnenberg,H. Sonnenberg +7 more
TL;DR: It is concluded that the atrial extract contained an extremely powerful inhibitor of renal tubular NaCl re absorption, which caused a rapid, more than 30-fold increase of sodium and chloride excretions, while urine volume and potassium excretion doubled.
Journal Article
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.
TL;DR: The ability of these agents to increase cyclic GMP levels in intact tissues is probably due to their effects on guanylate cyclase activity.
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Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria.
Mark G. Currie,David M. Geller,Barbara R. Cole,John G. Boylan,Wu YuSheng,Sandra W. Holmberg,Philip Needleman +6 more
TL;DR: It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.
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Purification and sequence analysis of bioactive atrial peptides (atriopeptins)
Mark G. Currie,David M. Geller,Barbara R. Cole,Ned R. Siegel,Kam F. Fok,Steven Paul Adams,Shad R. Eubanks,Gerald R. Galluppi,Philip Needleman +8 more
TL;DR: Both peptides appear to be derived from a common high molecular weight precursor (designated atriopeptigen); their biological selectivity and potency may be determined by the site of carboxyl terminal cleavage.
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Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.
Nabil G. Seidah,Claude Lazure,M. Chrétien,Gaétan Thibault,Raul Garcia,Cantin M,J. Genest,Ruth F. Nutt,S F Brady,T. A. Lyle +9 more
TL;DR: The proposed primary structure agrees entirely with the amino acid composition and reveals no significant sequence homology with any known protein or segment of protein.