Journal ArticleDOI
A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
A. J. De Bold,A. J. De Bold,H.B. Borenstein,H.B. Borenstein,A. T. Veress,A. T. Veress,H. Sonnenberg,H. Sonnenberg +7 more
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TLDR
It is concluded that the atrial extract contained an extremely powerful inhibitor of renal tubular NaCl re absorption, which caused a rapid, more than 30-fold increase of sodium and chloride excretions, while urine volume and potassium excretion doubled.About:
This article is published in Life Sciences.The article was published on 1981-01-05. It has received 3051 citations till now. The article focuses on the topics: Atrial natriuretic peptide & Atrial volume receptors.read more
Citations
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Journal ArticleDOI
A new natriuretic peptide in porcine brain
TL;DR: The brain natriuretic peptide (BNP) as mentioned in this paper was identified in porcine brain of a novel peptide of 26 amino acid residues, eliciting a pharmacological spectrum very similar to that of ANP.
Journal Article
Guanylyl Cyclases and Signaling by Cyclic GMP
Kimberly A. Lucas,Giovanni Pitari,Giovanni Pitari,Shiva Kazerounian,Inez Ruiz-Stewart,Jason Y. Park,Stephanie Schulz,Kenneth P. Chepenik,Scott A. Waldman +8 more
TL;DR: Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP as mentioned in this paper, and they are regulated by diverse extracellular agonists that include peptide hormones, bacterial toxins, and free radicals, as well as intracellular molecules such as calcium and adenine nucleotides.
Journal ArticleDOI
Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Kenji Kangawa,Hisayuki Matsuo +1 more
TL;DR: A survey for natriuretic factors in human atrial extract was performed by using in vitro assay for the relaxant effect on the contractility of chick rectum.
Journal ArticleDOI
B-type natriuretic peptide in cardiovascular disease
TL;DR: Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on.
Journal ArticleDOI
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions.
TL;DR: The structure, function, regulation, and biological consequences of natriuretic peptides and their associated signaling proteins are described.
References
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Journal ArticleDOI
Heart atria granularity effects of changes in water-electrolyte balance
TL;DR: It was found that water deprivation and sodium deficiency lead to atrial hypergranulation, whereas, the combined administration of desoxycorticosterone and NaCl in the drinking water leads to degranulation.
Journal ArticleDOI
Cardionatrin I — A novel heart peptide with potent diuretic and natriuretic properties
TL;DR: It was found that when rat atrial extracts are subjected to reverse phase-high pressure liquid chromatography, diuretic and natriuretic activities are recovered in four distinct chromatographic regions.
Journal ArticleDOI
Effects of flow rate and potassium intake on distal tubular potassium transfer.
RN Khuri,WN Strieder,G Giebisch +2 more
TL;DR: It is suggested that whenever sodium delivery stimulates distal Tubular potassium secretion it does so by increasing volume distal tubular potasssium secretion and by augmenting the transepithelial electrical potential difference (lumen negative).
Journal ArticleDOI
Cardiac receptors and fluid volume control.
TL;DR: Evidence is presented that volume is regulated as an independent parameter, and growing evidence of nervous connections between mechanical events in the heart and the central adjustment of water and mineral excretion promises to throw light on the puzzling metabolic changes in congestive heart failure and a number of other cardiovascular disturbances.
Journal ArticleDOI
Atrial specific granules of the rat heart: light microscopic staining and histochemical reactions.:
TL;DR: Assessment of reactions suggests that atrial granules are a site of storage for a protein or polypeptide and some of the tests indicate that these may contain tryptophan and sulfur-containing amino acids.
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Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)
Kenji Kangawa,Hisayuki Matsuo +1 more