Journal ArticleDOI
Vitamin E TPGS as a molecular biomaterial for drug delivery
TLDR
TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles.About:
This article is published in Biomaterials.The article was published on 2012-06-01. It has received 501 citations till now. The article focuses on the topics: Targeted drug delivery & Drug delivery.read more
Citations
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siRNA Versus miRNA as Therapeutics for Gene Silencing
TL;DR: This review provides a comparison between therapeutic siRNAs and miRNAs in terms of their mechanisms of action, physicochemical properties, delivery, and clinical applications and the challenges in developing both classes of RNA as therapeutics.
Journal ArticleDOI
Nanotheranostics ˗ Application and Further Development of Nanomedicine Strategies for Advanced Theranostics
TL;DR: This review summarizes the various nanocarriers developed so far in the literature for nanotheranostics, which include polymer conjugations, dendrimers, micelles, liposomes, metal and inorganic nanoparticles, carbon nanotubes, and nanoparticles of biodegradable polymers for sustained, controlled and targeted co-delivery of diagnostic and therapeutic agents for better theranostic effects with fewer side effects.
Journal ArticleDOI
The applications of Vitamin E TPGS in drug delivery.
TL;DR: TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, adjuvant in vaccine systems, nutrition supplement, plasticizer of film, anticancer reagent and so on are discussed.
Journal ArticleDOI
Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
Wei Xu,Peixue Ling,Tianmin Zhang +2 more
TL;DR: The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.
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Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform
Bivash Mandal,Himanshu Bhattacharjee,Nivesh K. Mittal,Hongkee Sah,Pavan Balabathula,Laura A. Thoma,George C. Wood +6 more
TL;DR: This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system.
References
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Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
TL;DR: Stealth liposomes can be actively targeted with monoclonal antibodies or ligands and encapsulating active molecules, with high target efficiency and activity by synthetic modification of the terminal PEG molecule.
Journal ArticleDOI
Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.
Khin Yin Win,Si-Shen Feng +1 more
TL;DR: It is highly feasible for nanoparticles of biodegradable polymers to be applied to promote oral chemotherapy by using Caco-2 cells, showing that surface modification of PLGA nanoparticles with vitamin E TPGS notably improved the cellular uptake.
Journal ArticleDOI
Effective drug delivery by PEGylated drug conjugates.
TL;DR: An update of drug delivery using poly(ethylene glycol) (PEG), that focuses on recent developments in both protein and organic drugs, is presented, that includes applications of high molecular weight PEG prodrug strategies to amino containing drugs.
Journal ArticleDOI
A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.
L Mu,Si-Shen Feng +1 more
TL;DR: Vitamin E TPGS has great advantages for the manufacture of polymeric nanoparticles for controlled release of paclitaxel and other anti-cancer drugs and could be a novel surfactant as a matrix material when blended with other biodegradable polymers.
Related Papers (5)
Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)
Formulation of Docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS2k) micelles for targeted and synergistic chemotherapy
Yu Mi,Yutao Liu,Si-Shen Feng +2 more