What Is Next in Single-Chain Nanoparticles?
TLDR
Interest in this field continues to grow partially due to the variety of potential applications of SCNP including catalysis, sensors, nanoreactors, and nanomedicine.Abstract:
With the increasing appeal of nanotechnology, there is a demand for development of synthetic techniques for the fabrication of nano-sized objects that allow for precise size control and tailored functionalization. To this end, the collapse or folding of single polymer chains into architecturally defined nanostructures is a rapidly growing research topic in polymer science. Many synthetic approaches have been developed for the formation of single-chain nanoparticles (SCNP), and a variety of characterization methods and computational efforts have been utilized to detail their formation and probe their morphological characteristics. Interest in this field continues to grow partially due to the variety of potential applications of SCNP including catalysis, sensors, nanoreactors, and nanomedicine. While numerous developments have been made, the field is continuing to evolve, and there are still many unanswered questions regarding synthesis and characterization of SCNP. This Perspective serves to identify recen...read more
Citations
More filters
Journal ArticleDOI
From precision polymers to complex materials and systems
TL;DR: In this paper, the authors highlight that most of the necessary elements for the development of more complex synthetic matter are available today using modern strategies, such as controlled radical polymerizations, supramolecular polymerizations or stepwise synthesis, polymers with precisely controlled molecular structures can be synthesized.
Journal ArticleDOI
Single-Chain Nanoparticles as Catalytic Nanoreactors
Hannah Rothfuss,Hannah Rothfuss,Nicolai D. Knöfel,Peter W. Roesky,Peter W. Roesky,Christopher Barner-Kowollik,Christopher Barner-Kowollik +6 more
TL;DR: In this article, a pathway mimics a metallo-enzyme's tertiary structure via the target placement of metal-ions in a tailor-made polymeric framework, resulting in catalytically active single-chain nanoparticles.
Journal ArticleDOI
Precision Self-Assembly of Amphiphilic Random Copolymers into Uniform and Self-Sorting Nanocompartments in Water
TL;DR: In this article, the authors report that the nanoparticles allow the on-target and predictable control of size, molecular weight, and aggregation number by tuning the primary structure of the copolymers.
Journal ArticleDOI
Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions
TL;DR: In this article, the shape anisotropy at the nanoscale has emerged as a potent way to access new properties and functionality, enabling the exploration of complex nanomaterials across a range of applications.
Journal ArticleDOI
Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging
W. Russ Algar,Melissa Massey,Kelly Rees,Rehan Higgins,Katherine D Krause,Ghinwa H. Darwish,William J. Peveler,Zhujun Xiao,Hsin-Yun Tsai,Rupsa Gupta,Kelsi Lix,Michael V. Tran,Hyungki Kim +12 more
TL;DR: This review provides a comprehensive and heuristic overview of luminescent nanoparticles, targeted to both newcomers and experts who are interested in a critical assessment of LNP materials, their properties, strengths and weaknesses, and prospective applications.
References
More filters
Journal ArticleDOI
Principles that Govern the Folding of Protein Chains
TL;DR: Anfinsen as discussed by the authors provided a sketch of the rich history of research that provided the foundation for his work on protein folding and the Thermodynamic Hypothesis, and outlined potential avenues of current and future scientific exploration.
Journal ArticleDOI
Protein folding and misfolding
TL;DR: The manner in which a newly synthesized chain of amino acids transforms itself into a perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence and on multiple contributing influences from the crowded cellular milieu.
Journal ArticleDOI
About Dendrimers: Structure, Physical Properties, and Applications
Journal ArticleDOI
How Fast-Folding Proteins Fold
TL;DR: Results of atomic-level molecular dynamics simulations of 12 proteins reveal a set of common principles underlying the folding of 12 structurally diverse proteins that spontaneously and repeatedly fold to their experimentally determined native structures.
Journal ArticleDOI
Sequence-controlled polymers.
TL;DR: This work reviews the progress that has been made in making sequence-controlled polymers of increasing length and complexity and proposes some strategies for controlling sequences in chain-growth and step-growth polymerizations.