Journal ArticleDOI
Withania somnifera (Ashwagandha), a Rejuvenating Herbal Drug Which Controls Alpha-2-Macroglobulin Synthesis During Inflammation
K. Anbalagan,J. Sadique +1 more
- Vol. 23, Iss: 4, pp 177-183
TLDR
Unlike non-steroidal anti-in-flammatory drugs, W. somnifera treatment resulted in a specific decrease in the synthesis of alpha-2-macroglobulin and enhancement in thehesis of total serum proteins suggesting the basis for its wide spectrum of pharmacological activities in diseases involving alterations of serum proteins.Abstract:
Withania somnifera Dun. herbal drug widely used in Indian medicinal systems, was examined for its effect on alpha-2-macroglobulin. Administration of W. somnifera to inflamed rats caused a significant reduction in the level of serum alpha-2-macroglobulin. Unlike non-steroidal anti-in-flammatory drugs, W. somnifera treatment resulted in a specific decrease in the synthesis of alpha-2-macroglobulin and enhancement in the synthesis of total serum proteins suggesting the basis for its wide spectrum of pharmacological activities in diseases involving alterations of serum proteins.read more
Citations
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Journal ArticleDOI
Current Status of Withania somnifera (L.) Dunal: An Endangered Medicinal Plant from Himalaya
Sumaira Aslam,Naveed Iqbal Raja,Mubashir Hussain,Muhammad Iqbal,Muhammad Ejaz,Danish Ashfaq,Hira Fatima,Muhammad Ali Shah,nbsp Abd-Ur-Rehman,Maria Ehsan +9 more
TL;DR: Withania somnifera is highly medicinal plant species of Pakistan floristically placed in the Western Himalayan Province, Himalaya Range of Azad Jammu and Kashmir and in the Soon valley (Salt Range) of Punjab Pakistan and acquires much therapeutic potential which include sedative, narcotic, thyroid stimulation, anti-inflammatory, hypnotic,anti-stress, general tonic, diuretic, antimicrobial, and antitumor activities.
Journal ArticleDOI
Suppressive Effect Of Withania Somnifera Root Extract on the Induction of Anti-Ovalbumin IgE Antibody Response in Mice
TL;DR: Withania somnifera Dunal (Solanaceae) (WS), a well known Indian herbal drug, was examined for its effect on downregulation of antigen-specific IgE antibody response in mice and suppressed the antigen- specific IgE antibodies response against other allergens tested in BALB/c mice.
Book ChapterDOI
The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders
TL;DR: Ashwagandha extracts have been shown to possess anti-inflammatory-immunomodulatory, antioxidant, cortisol lowering, anti-stress, pro-cholinergic, antiglutamatergic and neuroprotective properties, the very processes that are thought to underlie cognitive impairments not only in in bipolar disorder but also in other psychiatric disorders as discussed by the authors.
References
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Journal ArticleDOI
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
TL;DR: The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
Journal ArticleDOI
The alpha macroglobulins of rat serum.
TL;DR: The three methods successively used, namely gel filtration, ultracentrifugation and chromatography on DEAE-cellulose, were chosen to minimize loss of tryptic esterase-protecting activity in the serum of normal and injured rats.
Journal ArticleDOI
Withania Somnifera (Ashwagandha), a Rejuvenating Herbal Drug Which Enhances Survival During Stress (an Adaptogen)
TL;DR: Withania somnifera, herbal rejuvenative tonic widely used by Ayurvedic physicians in India, was tested for its adaptogenic properties and appears to induce a state of non-specifically increased resistance (SNIR) during stress.
Journal ArticleDOI
Immunochemical detection of an acute-phase protein in rat serum.
TL;DR: A new protein designated α2-AP (acute phase) globulin, not present in normal rat serum, has been detected by immunochemical methods in a wide variety of pathologic states.