Wnt expression patterns in chick embryo nervous system.
TLDR
The timing and spatial distribution of Wnt-gene expression in the chick embryo further support the general hypothesis that Wnt genes play key roles in patterning the developing vertebrate nervous system.About:
This article is published in Mechanisms of Development.The article was published on 1995-07-01 and is currently open access. It has received 274 citations till now. The article focuses on the topics: Neural tube & Neural plate.read more
Citations
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Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
Véronique Brault,Robert Moore,Stefanie Kutsch,Makoto Ishibashi,David H. Rowitch,Andrew P. McMahon,Lukas Sommer,Oreda Boussadia,Rolf Kemler +8 more
TL;DR: The results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development, and analysis of neural tube explants shows that (beta- catenin is efficiently deleted in migrating neural crest cell precursors), suggests that removal of Beta-Catenin affects Neural crest cell survival and/or differentiation.
Journal ArticleDOI
Diversity and Pattern in the Developing Spinal Cord
Yasuto Tanabe,Thomas M. Jessell +1 more
TL;DR: This work uses the spinal cord as a model system for analyzing the molecular control of central nervous system development in vertebrates and reveals the identity and mechanism of action of molecules that induce and pattern neural tissue and the role of transcription factors in establishing generic and specific neuronal fates.
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Midbrain development induced by FGF8 in the chick embryo
TL;DR: It is reported that FGF8 protein has the same midbrain-inducing and polarizing effect as isthmic tissue and induces ectopic expression in theForebrain of genes normally expressed in the isthmus, suggesting that the ectopic midbrain forms under the influence of signals from a new 'isthmus-like' organizing centre induced in the forebrain.
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A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
TL;DR: Evidence is presented that dorsal-ventral growth of the developing spinal cord is regulated by a Wnt mitogen gradient, and several lines of evidence suggesting that dorsal midline Wnts form a dorsal to ventral concentration gradient.
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WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
TL;DR: Manipulation of the WNT pathways could provide new strategies for nerve regeneration and neuronal circuit modulation.
References
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A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
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Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
Charles Auffray,François Rougeon +1 more
TL;DR: A procedure is described for the large-scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice by oligo(dT)-cellulose chromatography and either sucrose gradient centrifugation in conditions preventing aggregation or by means of high-resolution preparative gel electrophoresis under non-denaturing conditions.
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The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
Andrew P. McMahon,Allan Bradley +1 more
TL;DR: The Wnt-1 (int-1) proto-oncogene, which encodes a putative signaling molecule, is expressed exclusively in the developing central nervous system and adult testes and its normal role is in determination or subsequent development of a specific region of thecentral nervous system.
Book
In situ hybridization: a practical approach
TL;DR: This edition has been thoroughly updated to contain protocols detailing the major techniques of "in situ" hybridization currently in use in the late 1990s: " in situ" Hybridization to mRNA with oligonucleotide and RNA probes (radiolabelled and hapten labelled); analysis using light and electron microscopes.
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Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
TL;DR: It is reported here that the expression of Wnt-4, which encodes a secreted glycoprotein, correlates with, and is required for, kidney tubulogenesis and appears to act as an autoinducer of the mesenchyme to epithelial transition that underlies nephron development.