Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
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The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants and appear to be initiated at the neural plate stage and to involve the opponent activities of a BMP-mediated dorsalizing signal from the epidermal ectoderm and a SHH-mediated ventralizing signalFrom the notochord.About:
This article is published in Cell.The article was published on 1995-09-22 and is currently open access. It has received 1080 citations till now. The article focuses on the topics: Neural plate & Neural fold.read more
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Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
TL;DR: The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor suppressor protein that is defective in basal cell nevus syndrome (BCNS).
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The snail superfamily of zinc-finger transcription factors.
TL;DR: The Snail superfamily of zinc-finger transcription factors is involved in processes that imply pronounced cell movements, both during embryonic development and in the acquisition of invasive and migratory properties during tumour progression.
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The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
TL;DR: It is reported that noggin protein binds BMP4 with high affinity and can abolish B MP4 activity by blocking binding to cognate cell-surface receptors and these data suggest that nogsgin secreted by the organizer patterns the embryo by interrupting BMP signaling.
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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
Sonja Kriks,Jae-Won Shim,Jinghua Piao,Yosif Ganat,Dustin R. Wakeman,Zhi-Zhong Xie,Luis Carrillo-Reid,Gordon Auyeung,Chris Antonacci,Amanda Buch,Lichuan Yang,M. Flint Beal,D. James Surmeier,Jeffrey H. Kordower,Viviane Tabar,Lorenz Studer +15 more
TL;DR: A novel floor-plate-based strategy for the derivation of human DA neurons that efficiently engraft in vivo is presented, suggesting that past failures were due to incomplete specification rather than a specific vulnerability of the cells.
References
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A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
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A series of normal stages in the development of the chick embryo
TL;DR: In this article, a series of normal stages of the chick embryo is described in terms of the length of time of incubation, except for the first three days during which more detailed characteristics such as the number of somites are applied.
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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Yann Echelard,Douglas J. Epstein,Benoit St-Jacques,Liya Shen,Jym Mohler,Jill A. McMahon,Andrew P. McMahon +6 more
TL;DR: Three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh), are identified and it is suggested that Shh may play a role in the normal inductive interactions that pattern the ventral CNS.
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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
TL;DR: Four areas have seen major progress in the TGF-p superfamily in the last 3 years: structural characterization of the signal ing molecule, isolation of new family members, cloning of receptor molecules, and new genetic tests of the func tions of these factors in different organisms.
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Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development
Ichiro Satokata,Richard L. Maas +1 more
TL;DR: The Msx1 homeobox gene has a critical role in mediating epithelial–mesenchymal interactions during craniofacial bone and tooth development, and provides a genetic model for cleft palate and oligodontia in which the defective gene is known.