Journal ArticleDOI
Midbrain development induced by FGF8 in the chick embryo
TLDR
It is reported that FGF8 protein has the same midbrain-inducing and polarizing effect as isthmic tissue and induces ectopic expression in theForebrain of genes normally expressed in the isthmus, suggesting that the ectopic midbrain forms under the influence of signals from a new 'isthmus-like' organizing centre induced in the forebrain.Abstract:
VERTEBRATE midbrain development depends on an organizing centre located at the isthmus, a constriction in the embryonic mid/hindbrain region1–3,28. Isthmic tissue grafts transform chick caudal forebrain into an ectopic midbrain that is the mirror image of the normal midbrain4. Here we report that FGF8 protein has the same midbrain-inducing and polarizing effect as isthmic tissue. Moreover, FGF8 induces ectopic expression in the forebrain of genes normally expressed in the isthmus, suggesting that the ectopic midbrain forms under the influence of signals from a new 'isthmus-like' organizing centre induced in the forebrain. Because Fgf8 itself is expressed in the isthmus, our results identify FGF8 as an important signalling molecule in normal midbrain development.read more
Citations
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The Fibroblast Growth Factor signaling pathway
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning.
Journal ArticleDOI
Stem cells in the central nervous system.
TL;DR: The development of therapies for the reconstruction of the diseased or injured brain will be guided by the understanding of the origin and stability of cell type in the central nervous system.
Journal ArticleDOI
Fibroblast growth factors, their receptors and signaling.
TL;DR: FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.
Journal ArticleDOI
Patterning the Vertebrate Neuraxis
Andrew Lumsden,Robb Krumlauf +1 more
TL;DR: Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.
Journal ArticleDOI
The ephrins and eph receptors in neural development
TL;DR: The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps, and may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system.
References
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Journal ArticleDOI
A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
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The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
Andrew P. McMahon,Allan Bradley +1 more
TL;DR: The Wnt-1 (int-1) proto-oncogene, which encodes a putative signaling molecule, is expressed exclusively in the developing central nervous system and adult testes and its normal role is in determination or subsequent development of a specific region of thecentral nervous system.
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The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
TL;DR: It appears that Fgf8 is structurally the most complex member of the FGF family described to date, with at least seven transcripts encoding a family of secreted FGF8 proteins with different N termini.
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Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.
Kirk R. Thomas,Mario R. Capecchi +1 more
TL;DR: The function of int–1 in the mouse is explored by disrupting one of the two int-1 alleles in mouse embryo-derived stem cells using positive–negative selection and generating a chimaeric mouse that transmitted the mutant allele to its progeny.
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Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
TL;DR: Evidence is provided that FGF8 serves as an endogenous inducer of chick limb formation and that its expression in the intermediate mesoderm at the appropriate time and place to trigger forelimb development is directly linked to the mechanism of embryonic kidney differentiation.