Journal ArticleDOI
Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic
Martin C.H. Gruhlke,Ivan Schlembach,Roman Leontiev,Andreas Uebachs,Peter U.G. Gollwitzer,Alexander Weiss,Agnès Delaunay,Michel B. Toledano,Alan J. Slusarenko +8 more
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TLDR
Data suggest that Yap1p is an important transcriptional regulator for the resistance of yeast cells to allicin, and that activation occurs by direct modification of C‐term cysteines as shown for other electrophiles.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2017-07-01. It has received 26 citations till now. The article focuses on the topics: Allicin.read more
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A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin.
Roman Leontiev,Roman Leontiev,Nils Hohaus,Claus Jacob,Martin C.H. Gruhlke,Alan J. Slusarenko +5 more
TL;DR: Thiosulfinates differed in their effectivity against specific organisms and some were thermally more stable than allicin, which could be suitable for applications in medicine and agriculture either singly or in combination with other antimicrobials.
Journal ArticleDOI
Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor
Jana Reiter,Natalja Levina,Mark van der Linden,Martin C.H. Gruhlke,Christian Martin,Alan J. Slusarenko +5 more
TL;DR: Since there are no volatile antibiotics available to treat pulmonary infections, allicin, particularly at sublethal doses in combination with oral antibiotics, could make a valuable addition to currently available treatments.
Journal ArticleDOI
Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress.
Vu Van Loi,Nguyen Thi Thu Huyen,Tobias Busche,Quach Ngoc Tung,Martin C.H. Gruhlke,Jörn Kalinowski,Jörg Bernhardt,Alan J. Slusarenko,Haike Antelmann +8 more
TL;DR: Phenotype and biochemical analyses revealed that BSH and the HypR-controlled disulfide reductase MerA are involved in allicin detoxification in S. aureus and the reversal of protein S-thioallylation was catalyzed by the Brx/BSH/YpdA pathway.
Journal ArticleDOI
Yap1 homologs mediate more than the redox regulation of the antioxidant response in filamentous fungi.
TL;DR: In filamentous fungi, Yap1 homologs are involved in a wider array of processes by regulating genes involved in nutrient assimilation, secondary metabolism, virulence and development, which illustrate the divergent roles of ROS and other oxidizing compounds as important regulatory signaling molecules.
Journal ArticleDOI
Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin's Effects on Cells.
Jan Borlinghaus,Jana Reiter,Ulrike Kappler,Haike Antelmann,Ulrike Noll,Martin C.H. Gruhlke,Alan J. Slusarenko +6 more
TL;DR: The volatile organic sulfur compound allicin (diallyl thiosulfinate) is produced as a defense substance when garlic (Allium sativum) tissues are damaged, for example by the activities of pathogens or pests as mentioned in this paper.
References
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Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
TL;DR: DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation of the temporal program of gene expression accompanying the metabolic shift from fermentation to respiration, and the expression patterns of many previously uncharacterized genes provided clues to their possible functions.
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The small, versatile pPZP family of Agrobacterium binary vectors for plant transformation
TL;DR: The newpPZP Agrobacterium binary vectors are versatile, relatively small, stable and fully sequenced, allowing their use inAgrobacteria strains with different drug resistance markers.
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A Thiol Peroxidase Is an H2O2 Receptor and Redox-Transducer in Gene Activation
TL;DR: The glutathione peroxidase-like enzyme Gpx3 is identified as a second component of the pathway, serving the role of sensor and transducer of the hydroperoxide signal to Yap1, revealing a redox-signaling function for a GPx- like enzyme and elucidate a eukaryotic Hydroperoxide-sensing mechanism.