Journal ArticleDOI
Zinc requirements and the risks and benefits of zinc supplementation
TLDR
A multidisciplinary approach will most likely result in success in the pharmacology of zinc compounds as a promising area for translational research, and the current assumed range between safe and unsafe intakes of zinc is relatively narrow.About:
This article is published in Journal of Trace Elements in Medicine and Biology.The article was published on 2006-05-10. It has received 920 citations till now. The article focuses on the topics: Zinc toxicity & Zinc deficiency.read more
Citations
More filters
Journal ArticleDOI
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants
TL;DR: A deep understanding of the mechanisms involved in eliciting heavy metals toxicity is provided in order to highlight the necessity for development of strategies to decrease exposure to these metals, as well as to identify substances that contribute significantly to overcome their hazardous effects within the body of living organisms.
Journal ArticleDOI
The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.
TL;DR: This review summarizes current progress in the understanding of each ZnT and ZIP transporter from the perspective of zinc physiology and pathogenesis, discussing challenging issues in their structure and zinc transport mechanisms.
Journal Article
Zinc and its importance for human health: An integrative review.
TL;DR: A review on zinc biochemical and physiological functions, metabolism including, absorption, excretion, and homeostasis, zinc bio-availability (inhibitors and enhancers), human requirement, groups at high-risk, consequences and causes of zinc deficiency, evaluation of zinc status, and prevention strategies of zinc deficiencies are provided.
Journal ArticleDOI
Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life
TL;DR: It is fair to conclude that the impact of zinc for health and disease will be at least as far-reaching as that of iron.
Journal ArticleDOI
Zinc and its role in immunity and inflammation
TL;DR: This review aims at describing the mechanisms involved in the regulation of Zn homeostasis and their effects on the immune response focusing on those which are implicated in the physiopathology of rheumatoid arthritis.
References
More filters
Journal ArticleDOI
Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc.
TL;DR: The DRIs represent the new approach adopted by the Food and Nutrition Board to providing quantitative estimates of nutrient intakes for use in a variety of settings, replacing and expanding on the past 50 years of periodic updates and revisions of the Recommended Dietary Allowances.
Journal ArticleDOI
The biochemical basis of zinc physiology
TL;DR: Majors topics addressed in this review on zinc physiology are chemistry and biochemistry; interface of biochemistry and physiology of zinc; physiology and cell and molecular biology; and pathology.
Journal ArticleDOI
Transposable elements: targets for early nutritional effects on epigenetic gene regulation.
TL;DR: The results show that dietary methyl supplementation of a/a dams with extra folic acid, vitamin B12, choline, and betaine alter the phenotype of their Avy/a offspring via increased CpG methylation at the AvY locus and that the epigenetic metastability which confers this lability is due to the Avy transposable element.
Journal ArticleDOI
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
Jeremy M Berg,Yigong Shi +1 more
TL;DR: The ability of zinc to be bound specifically within a range of tetrahedral sites appears to be responsible for the evolution of the wide range of zinc-stabilized structural domains now known to exist.