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Does the Covid vaccine use synthetic RNA? 

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Papers (10)Insight
Open accessJournal ArticleDOI
Ehtisham Ul Haq, Jifeng Yu, Jiancheng Guo 
16 Citations
COVID-19 vaccine efforts mark the first use of mRNA-type vaccines ever evaluated.
Journal ArticleDOI
Georgetta Cannon, Drew Weissman 
105 Citations
RNA, on the other hand, is readily taken up and expressed by DC, making it an alternative vaccine candidate.
Synthetic mRNA represents an exciting cancer vaccine technology to the implementation of effective cancer immunotherapy.
Therefore, RNA adjuvants have broad applicability and can be used with all conventional vaccines to improve vaccine efficacy qualitatively and quantitively.
We conclude that the self-replicative recombinant SFV RNA may be quite useful as a nucleic acid vaccine.
Thus, disruption of conserved RNA secondary structures could be a novel strategy for the generation of attenuated SARS-CoV-2 vaccines for use against the current COVID-19 pandemic.
Our findings suggest that the nucleoside-modified mRNA-LNP vaccine platform can induce robust immune responses and is a promising candidate to combat COVID-19.
Altogether, synthetic biology can help to develop improved vaccine candidates in considerably less time compared to conventional approaches.
This demonstrates that DNA vaccine potency may be augmented by the incorporation of RIG-I-activating immunostimulatory RNA into the vector backbone.
The RNA initiates limited replication of a genetically defined, live-attenuated vaccine virus in the tissues of the vaccine recipient, thereby inducing a protective immune response.