Cricket paralysis virus internal ribosome entry site-derived RNA promotes conventional vaccine efficacy by enhancing a balanced Th1/Th2 response.
Hye Won Kwak,Hyo Jung Park,Hae Li Ko,Hye-Lim Park,Min Ho Cha,Sang-Myeong Lee,Kyung Won Kang,Rhoon-Ho Kim,Seung Rok Ryu,Hye-Jung Kim,Jae-Ouk Kim,Manki Song,Hun Kim,Dae Gwin Jeong,Eui-Cheol Shin,Jae-Hwan Nam +15 more
TLDR
Application of the RNA adjuvant in mouse enhanced the efficacy of Middle East respiratory syndrome spike protein, a protein-subunit vaccine and human papillomavirus L1 protein by activating innate immune response through TLR7 and enhancing pAPC chemotaxis, leading to a balanced Th1/Th2 responses.About:
This article is published in Vaccine.The article was published on 2019-07-29 and is currently open access. It has received 15 citations till now. The article focuses on the topics: Adjuvant & Vaccine efficacy.read more
Citations
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Journal ArticleDOI
Adjuvants for Coronavirus Vaccines.
Zhihui Liang,Haoru Zhu,Xin Wang,Bo Jing,Zifan Li,Xia Xinyu,Hongwu Sun,Yun Yang,Weiting Zhang,Li Shi,Hao Zeng,Bingbing Sun +11 more
TL;DR: An overview of adjuvants that have been formulated in reported coronavirus vaccine studies is presented, which should assist with the design and selection of adjvants with optimal efficacy and safety profiles for COVID-19 vaccines.
Journal ArticleDOI
Inactivated influenza vaccine formulated with single-stranded RNA-based adjuvant confers mucosal immunity and cross-protection against influenza virus infection.
Yun-Hee Kim,Yoo-Jin Bang,Hyo Jung Park,Hae Li Ko,Sang-In Park,Kyung-Ah Hwang,Hun Kim,Jae-Hwan Nam +7 more
TL;DR: This ssRNA-adjuvanted seasonal inactivated subunit influenza vaccine might be the best influenza vaccine generating robust humoral and cellular immune responses and conferring cross-protective and long-term immunity.
Journal ArticleDOI
Mers-cov spike protein vaccine and inactivated influenza vaccine formulated with single strand rna adjuvant induce t-cell activation through intranasal immunization in mice
Hye-Jung Kim,Hye Won Kwak,Kyung Won Kang,Yoo-Jin Bang,Yu-Sun Lee,Hyeong-Jun Park,Jae Yong Kim,Hyo Jung Park,Kyung-Ah Hwang,Sang-Myeong Lee,Jae-Hwan Nam +10 more
TL;DR: The immunological differences between two types of vaccines—spike protein from the Middle East respiratory syndrome virus and inactivated influenza virus vaccine, in combination with a single-stranded RNA adjuvantadministered through various routes (intramuscular, intradermal, and intranasal) to BALB/c mice are investigated.
Journal ArticleDOI
Quaternized Cationic Carbon Dots as Antigen Delivery Systems for Improving Humoral and Cellular Immune Responses
Shaomei Huang,Bowen Li,Usama Ashraf,Qi Li,Xingchang Lu,Xiaochen Gao,Min Cui,Muhammad Imran,Jing Ye,Fei-Fei Cao,Jiangjiang Gu,Shengbo Cao +11 more
TL;DR: The current licensed adjuvant alum is found insufficient to induce cellular immune response and balanced Th1/Th2 ratio, which is a key to induce potent immune responses in vaccines.
Journal ArticleDOI
Cell-Penetrating Peptides-Based Liposomal Delivery System Enhanced Immunogenicity of Peptide-Based Vaccine against Group A Streptococcus.
Jieru Yang,Farrhana Firdaus,Armira Azuar,Zeinab G. Khalil,Nirmal Marasini,Robert J. Capon,Waleed M. Hussein,Istvan Toth,Mariusz Skwarczynski +8 more
TL;DR: In this article, the authors used CPPs to deliver their lead lipopeptide-based vaccine (LCP-1), anchored through a spacer to LCP-1-bearing multilamellar and unilameLLar liposomes and administered to Swiss outbred mice.
References
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Journal ArticleDOI
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Troy D. Querec,Rama Akondy,Eva K. Lee,Weiping Cao,Helder I. Nakaya,Dirk E. Teuwen,Ali A. Pirani,Kim M. Gernert,Jiusheng Deng,Bruz Marzolf,Kathleen A. Kennedy,Haiyan Wu,Soumaya Bennouna,Herold Oluoch,Joseph I. Miller,Ricardo Z. N. Vêncio,Mark J. Mulligan,Alan Aderem,Rafi Ahmed,Bali Pulendran,Bali Pulendran +20 more
TL;DR: This article used a system biology approach to identify early gene signatures that predicted immune responses in humans vaccinated with the yellow fever vaccine YF-17D, with up to 90% accuracy in an independent, blinded trial.
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Towards an understanding of the adjuvant action of aluminium
TL;DR: The initial discovery of aluminium adjuvants was first discovered empirically in 1926 and their implications and the remaining questions on how these adjuvant work are discussed.
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Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
Denis Gaucher,René Therrien,Nadia Kettaf,Bastian R. Angermann,Geneviève Boucher,Abdelali Filali-Mouhim,Janice M. Moser,Riyaz Mehta,Donald Drake,Erika Castro,Rama Akondy,Aline Rinfret,Bader Yassine-Diab,Elias A. Said,Younes Chouikh,Mark J. Cameron,Robert Clum,David J. Kelvin,Roland Somogyi,Larry D. Greller,Robert S. Balderas,Peter Wilkinson,Giuseppe Pantaleo,Jim Tartaglia,Elias K. Haddad,Rafick Pierre Sekaly +25 more
TL;DR: The results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
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Mechanisms of action of adjuvants.
TL;DR: This review has summarized the recent progress in understanding of the mechanisms of action of adjuvants and provides critical information on how innate immunity influences the development of adaptive immunity.
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TLR-based immune adjuvants.
TL;DR: The nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants are described and those agents for which clinical results are available are reviewed.
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