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The geographic gradient in the frequency of the mutation, along with findings on polymorphic haplotype distribution, suggest that the mutation is relatively young in evolutionary terms and spread as the result of west and south‐bound migrations originating from Georgia.
Our novel methodology and online tools will make next-generation sequencing an easily applicable resource for mutation mapping in all model systems.
The search for mutation is also useful for the identification of the family members who do not carry the mutation and can avoid unnecessary biochemical and instrumental evaluations.
Our analysis also illustrates how the mutation rate may affect population differentiation, as different mutation rates result in different levels of homoplasy at microsatellite loci.
The results also give concrete suggestions on how to improve mutation analysis and reveal some inherent limitations.
The results show how prevalent redundant mutants are and how their elimination improves the efficiency and accuracy of mutation analysis.
Our study for the first time aimed to characterize the mutation profile of these genes in hearing loss patients of West Bengal state, India.
Mass awareness, education and genetic counselling are required to prevent the spread of this mutation among this tribal population of West Bengal.
Since it is so widespread in these West Bank populations, the IVS-I-6 mutation may date back to ancient times.
This variability is obviously connected with the population history of West Bengal.