Which grade of cancer contains the most differentiated cells?
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| The degree of differentiation in human cancers generally reflects the degree of malignancy, with the most undifferentiated cancer being also the highest grade and the most aggressive. | |
Open access•Journal Article 392 Citations | The cancer-derived differentiated cells are benign (12, 74) if not normal (39, 53) leading to the conclusion that attempts to direct normal differentiation of malignant stem cells might serve as an alternative to cytotoxic therapy. |
Open access 01 Nov 2016 614 Citations | We infer that most cancer cells are differentiated along two specialized glial programs, whereas a rare subpopulation of cells is undifferentiated and associated with a neural stem cell expression program. |
| These results Indicate that colorectal adenocarclnoma cells that are histologically subclassified as moderately differentiated have different proliferative and metastatic activities from cancer cells that are poorly differentiated. | |
17 Citations | Low-grade tumors could be differentiated from high-grade tumors. |
9 Citations | Different from the traditional point of view, the well differentiated cancer tissues have more alterations of important tumor-related genes than the poorly differentiated cancer tissues. |
| Thus, a subset of less differentiated cells exits the primary tumor but subsequently give rise to metastases that include a range of more differentiated and pigment-producing cells. | |
| Thus, malignant tumors are organized in a hierarchical fashion in which CSCs give rise to more differentiated tumor cells. | |
Open access•Journal Article 170 Citations | All existing grading systems successfully identify well-differentiated cancer, which progresses slowly, and poorly differentiated cancer, which progresses rapidly, but they are less successful in subdividing most moderately differentiated cancers, which have an intermediate malignant potential. |
38 Citations | Grading appears to be most difficult when cancer is present in multiple biopsies or it contains cribriform or fusion patterns. |
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