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A. Christine Munk
Researcher at Los Alamos National Laboratory
Publications - 27
Citations - 2608
A. Christine Munk is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Genome & Bacillus thuringiensis. The author has an hindex of 18, co-authored 27 publications receiving 2339 citations. Previous affiliations of A. Christine Munk include United States Department of Energy & Joint Genome Institute.
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Journal ArticleDOI
The genomic basis of trophic strategy in marine bacteria.
Federico M. Lauro,Diane McDougald,Torsten Thomas,Timothy J. Williams,Suhelen Egan,Scott A. Rice,Matthew Z. DeMaere,Lily Ting,Haluk Ertan,Haluk Ertan,Justin Johnson,Steven Ferriera,Alla Lapidus,Iain Anderson,Nikos C. Kyrpides,A. Christine Munk,Chris Detter,Cliff Han,Mark V. Brown,Frank T. Robb,Staffan Kjelleberg,Ricardo Cavicchioli +21 more
TL;DR: This work compares the genome sequences of two bacteria, Photobacterium angustum S14 and Sphingopyxis alaskensis RB2256, that serve as useful model organisms for copiotrophic and oligotrophic modes of life and relates the genomic features to trophic strategy for these organisms and defines their molecular mechanisms of adaptation.
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Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae.
Jongsik Chun,Christopher J. Grim,Nur A. Hasan,Jehee Lee,Seon Young Choi,Bradd J. Haley,Elisa Taviani,Yoon-Seong Jeon,Dong Wook Kim,Jaehak Lee,Thomas Brettin,David Bruce,Jean F. Challacombe,J. Chris Detter,Cliff Han,A. Christine Munk,Olga Chertkov,Linda Meincke,Elizabeth Saunders,Ronald A. Walters,Anwar Huq,G. Balakrish Nair,Rita R. Colwell +22 more
TL;DR: Based on the comparative genomics, it is concluded that V. cholerae undergoes extensive genetic recombination via lateral gene transfer, and, therefore, genome assortment, not serogroup, should be used to define pathogenic V.cholerae clones.
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Pathogenomic Sequence Analysis of Bacillus cereus and Bacillus thuringiensis Isolates Closely Related to Bacillus anthracis
Cliff Han,Gary Xie,Jean F. Challacombe,Michael R. Altherr,Smriti S. Bhotika,David Bruce,Connie S. Campbell,Mary L. Campbell,Jin Chen,Olga Chertkov,Cathy Cleland,Mira Dimitrijevic,Norman A. Doggett,John J. Fawcett,Tijana Glavina,Tijana Glavina,Lynne Goodwin,Karen K. Hill,Penny Hitchcock,Paul J. Jackson,Paul J. Jackson,Paul Keim,Avinash Ramesh Kewalramani,Jon Longmire,Susan Lucas,Susan Lucas,Stephanie Malfatti,Stephanie Malfatti,Kim McMurry,Linda Meincke,Monica Misra,Bernice L. Moseman,Mark Mundt,A. Christine Munk,Richard T. Okinaka,B. Parson-Quintana,Lee Philip Reilly,Paul Richardson,Paul Richardson,Donna L. Robinson,Eddy Rubin,Eddy Rubin,Elizabeth Saunders,Roxanne Tapia,Judith G. Tesmer,Nina Thayer,Linda S. Thompson,Hope Tice,Hope Tice,Lawrence O. Ticknor,Patti L. Wills,Thomas Brettin,Paul Gilna +52 more
TL;DR: Comparison of the genomes of two members of the B. cereus group revealed differences in terms of virulence, metabolic competence, structural components, and regulatory mechanisms, as well as shared and unique genes among these isolates in comparison to the genome of pathogenic strains B. anthracis Ames and B. cerealus.
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Temperature regulation of virulence factors in the pathogen Vibrio coralliilyticus
Nikole E. Kimes,Christopher J. Grim,Christopher J. Grim,Wesley R. Johnson,Nur A. Hasan,Ben D. Tall,Mahendra H. Kothary,Hajnalka Kiss,A. Christine Munk,Roxanne Tapia,Lance D. Green,Chris Detter,David Bruce,Thomas Brettin,Thomas Brettin,Rita R. Colwell,Rita R. Colwell,Pamela J. Morris +17 more
TL;DR: Evidence is provided that temperature regulates multiple virulence mechanisms in V. coralliilyticus, independent of abundance, which is reinforced by climate change models that predict tropical SST to consistently exceed 27 °C during the spring, summer and fall seasons.
Journal ArticleDOI
Analysis of the Neurotoxin Complex Genes in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1 Clusters Are Located within Plasmids
Theresa J. Smith,Karen K. Hill,Brian T. Foley,John C. Detter,A. Christine Munk,David Bruce,Norman A. Doggett,Leonard A. Smith,James D. Marks,Gary Xie,Thomas Brettin +10 more
TL;DR: Despite their size differences and the BoNT genes they contain, the three plasmids containing these toxin cluster genes share significant sequence identity, illustrating the different mechanisms by which these genes move among diverse genetic backgrounds of C. botulinum.