A
Aaron Massie
Researcher at Van Andel Institute
Publications - 4
Citations - 873
Aaron Massie is an academic researcher from Van Andel Institute. The author has contributed to research in topics: Germline mutation & Penetrance. The author has an hindex of 4, co-authored 4 publications receiving 832 citations.
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Journal ArticleDOI
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Gijs van Haaften,Gillian L. Dalgliesh,Helen Davies,Lina Chen,Graham R. Bignell,Christopher Greenman,Sarah Edkins,Claire Hardy,Sarah O’Meara,Jon W. Teague,Adam Butler,Jonathan Hinton,Calli Latimer,Jenny Andrews,Syd Barthorpe,Dave Beare,Gemma Buck,Peter J. Campbell,Jennifer Cole,Simon A. Forbes,Mingming Jia,David T. Jones,Chai Yin Kok,Catherine Leroy,Meng-Lay Lin,David J. McBride,Mark Maddison,Simon Maquire,Kirsten McLay,Andrew Menzies,Tatiana Mironenko,Lee Mulderrig,Laura Mudie,Erin Pleasance,Rebecca Shepherd,Raffaella Smith,Lucy Stebbings,Philip J. Stephens,Gurpreet Tang,Patrick S. Tarpey,Rachel Turner,Kelly Turrell,Jennifer Varian,Sofie West,Sara Widaa,Paul Wray,V. Peter Collins,Koichi Ichimura,Simon Law,John Wong,Siu Tsan Yuen,Suet Yi Leung,Giovanni Tonon,Giovanni Tonon,Ronald A. DePinho,Yu-Tzu Tai,Kenneth C. Anderson,Richard J. Kahnoski,Aaron Massie,Sok Kean Khoo,Bin Tean Teh,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +63 more
TL;DR: UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes, identifying UTX as a new human cancer gene.
Journal ArticleDOI
Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models.
Chao-Nan Qian,Kyle A. Furge,Jared Knol,Dan Huang,Jindong Chen,Karl Dykema,Eric J. Kort,Aaron Massie,Sok Kean Khoo,Kristin Vanden Beldt,James H. Resau,John Anema,Richard J. Kahnoski,Hans Morreau,Philippe Camparo,Eva Comperat,Mathilde Sibony,Yves Denoux,Vincent Molinié,Annick Vieillefond,Charis Eng,Bart O. Williams,Bin Tean Teh +22 more
TL;DR: An important role for the PI3K/AKT pathway is identified in the development of urothelial carcinoma and inhibitors of this pathway (e.g., mTOR inhibitor) may serve as effective therapeutic agents.
Journal ArticleDOI
Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma
Sok Kean Khoo,Pendek R,Radoslav Z. Nickolov,Douglas C. Luccio-Camelo,Newton Tl,Aaron Massie,David Petillo,J. Menon,D. F. Cameron,Bin Tean Teh,Siew Pheng Chan +10 more
TL;DR: The data showed that patients with the same mutation may express acromegalic features of differing severity, suggesting the existence of modifier genes, and shows the first genome-wide scan that identifies novel modifier loci for acromgalic phenotypes in an IFS family.
Journal ArticleDOI
Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC.
Daisuke Matsuda,Daisuke Matsuda,Sok Kean Khoo,Aaron Massie,Masatsugu Iwamura,Jindong Chen,David Petillo,Bill Wondergem,Michael Avallone,Stephanie J. Kloostra,Min-Han Tan,Min-Han Tan,Julie Koeman,Zhongfa Zhang,Richard J. Kahnoski,Shiro Baba,Bin Tean Teh,Bin Tean Teh +17 more
TL;DR: Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC.