Gijs van Haaften

TL;DR: UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes, identifying UTX as a new human cancer gene.

TL;DR: A screen identified 186 genes corresponding to five principal classes of polyglutamine regulators: genes involved in RNA metabolism, protein synthesis, protein folding, and protein degradation; and those involved in protein trafficking, proposing that each represents a molecular machine collectively comprising the protein homeostatic buffer that responds to the expression of damaged proteins to prevent their misfolding and aggregation.

TL;DR: A reporter-based RNAi screen for APA was developed and a novel function for PABPN1 was elucidated as a suppressor of APA, which causes autosomal-dominant oculopharyngeal muscular dystrophy and its sequestration in nuclear aggregates.

TL;DR: An RNA interference-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans, and 61 genes were identified; these also affect spontaneous mutagenesis in the germ line.

TL;DR: Using electrophysiological measurements, it is shown that mutations in ABCC9 reduce the ATP-mediated potassium channel inhibition, resulting in channel opening, and similarities between the phenotype of individuals with Cantú syndrome and side effects from the KATP channel agonist minoxidil indicate that the mutations inABCC9 result in channelOpening.