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Adi Blanc
Researcher at Duke University
Publications - 3
Citations - 707
Adi Blanc is an academic researcher from Duke University. The author has contributed to research in topics: G protein-coupled receptor & Arrestin. The author has an hindex of 3, co-authored 3 publications receiving 572 citations.
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Journal ArticleDOI
Visualization of arrestin recruitment by a G-protein-coupled receptor
Arun K. Shukla,Gerwin Westfield,Kunhong Xiao,Rosana I. Reis,Li-Yin Huang,Prachi Tripathi-Shukla,Jiang Qian,Sheng Li,Adi Blanc,Austin N. Oleskie,Anne M. Dosey,Min Su,Cui Rong Liang,Ling Ling Gu,Jin Ming Shan,Xin Chen,Rachel Hanna,Minjung Choi,Xiao Jie Yao,Bjoern U. Klink,Alem W. Kahsai,Sachdev S. Sidhu,Shohei Koide,Pawel A. Penczek,Anthony A. Kossiakoff,Virgil L. Woods,Brian K. Kobilka,Georgios Skiniotis,Robert J. Lefkowitz +28 more
TL;DR: A strategy for forming and purifying a functional human β2AR–β-arrestin-1 complex is devised that provides a framework for better understanding the basis of GPCR regulation by arrestins.
Journal ArticleDOI
Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
Thomas J. Cahill,Alex R.B. Thomsen,Jeffrey T. Tarrasch,Bianca Plouffe,Anthony H. Nguyen,Fan Yang,Li-Yin Huang,Alem W. Kahsai,Daniel L. Bassoni,Bryant J. Gavino,Jane Lamerdin,Sarah Triest,Sarah Triest,Arun K. Shukla,Arun K. Shukla,Benjamin Berger,John Little,Albert Antar,Adi Blanc,Chang Xiu Qu,Xin Chen,Kouki Kawakami,Asuka Inoue,Asuka Inoue,Junken Aoki,Junken Aoki,Jan Steyaert,Jan Steyaert,Jin-Peng Sun,Michel Bouvier,Georgios Skiniotis,Robert J. Lefkowitz +31 more
TL;DR: A mutant form of βarr lacking the “finger-loop” region is created, which is found that the tail conformation preserves the ability to mediate receptor internalization and βarr signaling but not desensitization of G protein signaling.
Journal ArticleDOI
Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping.
Kunhong Xiao,Yang Zhao,Minjung Choi,Hongda Liu,Adi Blanc,Jiang Qian,Thomas J. Cahill,Xue Li,Yunfang Xiao,Lisa J. Clark,Sheng Li +10 more
TL;DR: An orthogonal approach using hydrogen-deuterium-exchange mass spectrometry, cross-linking mass spectromaetry, and disulfide trapping to map interactions within protein complexes to characterize structural characterization of protein complexes.