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Austin N. Oleskie
Researcher at University of Michigan
Publications - 6
Citations - 924
Austin N. Oleskie is an academic researcher from University of Michigan. The author has contributed to research in topics: G protein-coupled receptor & Saccharomyces cerevisiae. The author has an hindex of 6, co-authored 6 publications receiving 808 citations. Previous affiliations of Austin N. Oleskie include Life Sciences Institute.
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Journal ArticleDOI
Visualization of arrestin recruitment by a G-protein-coupled receptor
Arun K. Shukla,Gerwin Westfield,Kunhong Xiao,Rosana I. Reis,Li-Yin Huang,Prachi Tripathi-Shukla,Jiang Qian,Sheng Li,Adi Blanc,Austin N. Oleskie,Anne M. Dosey,Min Su,Cui Rong Liang,Ling Ling Gu,Jin Ming Shan,Xin Chen,Rachel Hanna,Minjung Choi,Xiao Jie Yao,Bjoern U. Klink,Alem W. Kahsai,Sachdev S. Sidhu,Shohei Koide,Pawel A. Penczek,Anthony A. Kossiakoff,Virgil L. Woods,Brian K. Kobilka,Georgios Skiniotis,Robert J. Lefkowitz +28 more
TL;DR: A strategy for forming and purifying a functional human β2AR–β-arrestin-1 complex is devised that provides a framework for better understanding the basis of GPCR regulation by arrestins.
Journal ArticleDOI
Structural flexibility of the Gαs α-helical domain in the β 2-adrenoceptor Gs complex
Gerwin Westfield,Søren G. F. Rasmussen,Søren G. F. Rasmussen,Min Su,Somnath Dutta,Brian T. DeVree,Ka Young Chung,Diane Calinski,Gisselle A. Vélez-Ruiz,Austin N. Oleskie,Els Pardon,Pil Seok Chae,Tong Liu,Sheng Li,Virgil L. Woods,Jan Steyaert,Brian Kobilka,Roger K. Sunahara,Georgios Skiniotis +18 more
TL;DR: Molecular modeling of the α-helical domain in the 3D EM maps suggests that in its stabilized form it assumes a conformation reminiscent to the one observed in the crystal structure of Gαs-GTPγS.
Journal ArticleDOI
Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human
Yoh Hei Takahashi,Gerwin Westfield,Austin N. Oleskie,Raymond C. Trievel,Ali Shilatifard,Georgios Skiniotis +5 more
TL;DR: The minimum subunit composition required for histone H3K4 methylation is identified and this structural arrangement suggested that COMPASS family members function as exo-methylases, which is confirmed by in vitro and in vivo studies.
Journal ArticleDOI
The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.
Mithu De,Austin N. Oleskie,Mariam Ayyash,Somnath Dutta,Liliya V. Mancour,Mohamed E. Abazeed,Eddy J. Brace,Georgios Skiniotis,Robert S. Fuller +8 more
TL;DR: It is shown that Vps13p is directly required both for transport from the trans-Golgi network (TGN) to the late endosome/prevacuolar compartment (PVC) and for TGN homotypic fusion.
Journal ArticleDOI
Ligand-Induced Architecture of the Leptin Receptor Signaling Complex
Liliya V. Mancour,Hikmat N. Daghestani,Somnath Dutta,Gerwin Westfield,Gerwin Westfield,Justin Schilling,Austin N. Oleskie,Jeffrey F. Herbstman,Steven Z. Chou,Georgios Skiniotis,Georgios Skiniotis +10 more
TL;DR: It is proposed that the membrane proximal domain rigidification in the context of a liganded cytokine receptor dimer is a key mechanism for the transactivation of Janus kinases bound at the intracellular receptor region.