Alain Pesce

TL;DR: The multidomain intervention and polyunsaturated fatty acids, either alone or in combination, had no significant effects on cognitive decline over 3 years in elderly people with memory complaints.

TL;DR: The MAPT trial is presently the first largest and longest multidomain preventive trial relevant to cognitive decline in older adults with subjective memory complaints and is likely to be easily implemented within the general population.

TL;DR: Multidomain interventions, targeting multiple risk factors simultaneously, could be effective dementia prevention strategies, but may be burdensome and not universally acceptable.

TL;DR: Interestingly, the higher percentage of randomizations compared to screened participants is the personal contact source; almost 85 % of screened participants entered in the study; in an equivalent way, Medias and conferences are efficient recruiting sources to enrol volunteers in theStudy.

TL;DR: The recruitment and retention of patients are among the greatest challenges currently being faced by researchers who conduct Alzheimer's disease (AD) clinical trials and some recommendations aimed at overcoming these challenges are offered.