Alan L. Davis

TL;DR: The 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock continues to emphasize early use of age-specific therapies to attain time-sensitive goals, and a major new recommendation in the 2007 update is earlier use of inotrope support through peripheral access until central access is attained.

TL;DR: A major new recommendation in the 2014 update of the 2007 American College of Critical Care Medicine “Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock” is consideration of institution—specific use of a recognition bundle containing a trigger tool for rapid identification of patients with septic shock.

TL;DR: Rapid fluid resuscitation in excess of 40 mL/kg in the first hour following emergency department presentation was associated with improved survival, decreased occurrence of persistent hypovolemia, and no increase in the risk of cardiogenic pulmonary edema or adult respiratory distress syndrome in this group of pediatric patients with septic shock.

TL;DR: The American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Executive Summary are presented.

TL;DR: The plasma concentration of epinephrine correlates with the infusion rate, suggesting linear pharmacokinetics, and the clearance rates of two other inotropic catecholamines, dopamine and dobutamine, are significantly correlated with the clearance rate of Epinephrine.