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Alexander V. Ratushny
Researcher at Bristol-Myers Squibb
Publications - 56
Citations - 2010
Alexander V. Ratushny is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Gene regulatory network & Gene. The author has an hindex of 16, co-authored 53 publications receiving 1690 citations. Previous affiliations of Alexander V. Ratushny include Novosibirsk State University & Institute for Systems Biology.
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Journal ArticleDOI
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
John W. Schoggins,Donna A. MacDuff,Naoko Imanaka,Maria D. Gainey,Bimmi Shrestha,Jennifer L. Eitson,Katrina B. Mar,R. Blake Richardson,Alexander V. Ratushny,Vladimir Litvak,Rea Dabelic,Balaji Manicassamy,John D. Aitchison,Alan Aderem,Richard M. Elliott,Adolfo García-Sastre,Vincent R. Racaniello,Eric J. Snijder,Wayne M. Yokoyama,Michael S. Diamond,Herbert W. Virgin,Charles M. Rice +21 more
TL;DR: Comparative analysis reveals that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negative-sensesingle-strander RNA viruses.
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Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome
Ulrike Kusebauch,David S. Campbell,Eric W. Deutsch,Caroline S. Chu,Douglas A. Spicer,Mi-Youn Brusniak,Joseph Slagel,Zhi Sun,Jeffrey Stevens,Barbara Grimes,David Shteynberg,Michael R. Hoopmann,Peter Blattmann,Alexander V. Ratushny,Oliver Rinner,Paola Picotti,Christine Carapito,Chung-Ying Huang,Meghan Kapousouz,Henry H N Lam,Tommy Tran,Emek Demir,John D. Aitchison,John D. Aitchison,Chris Sander,Leroy Hood,Ruedi Aebersold,Ruedi Aebersold,Robert L. Moritz +28 more
TL;DR: The generation and verification of a compendium of highly specific assays that enable quantification of 99.7% of the 20,277 annotated human proteins by the widely accessible, sensitive, and robust targeted mass spectrometric method selected reaction monitoring, SRM are described.
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A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
Vladimir Litvak,Alexander V. Ratushny,Alexander V. Ratushny,Aaron E. Lampano,Frank Schmitz,Albert C. Huang,Ayush T. Raman,Alistair G. Rust,Andreas Bergthaler,John D. Aitchison,John D. Aitchison,Alan Aderem +11 more
TL;DR: The data suggest that the FOXO3–IRF7 regulatory circuit represents a novel mechanism for establishing the requisite set points in the interferon pathway that balances the beneficial effects and deleterious sequelae of the antiviral response.
Journal ArticleDOI
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.
Kelly N. DuBois,Sam Alsford,Jennifer M. Holden,Johanna Buisson,Michal Swiderski,Jean-Mathieu Bart,Alexander V. Ratushny,Alexander V. Ratushny,Yakun Wan,Philippe Bastin,J. David Barry,Miguel Navarro,David Horn,John D. Aitchison,John D. Aitchison,Michael P. Rout,Mark C. Field +16 more
TL;DR: NUP1, the first example of a nuclear lamin analog in nonmetazoans, performs roles similar to those of lamins in maintaining the structure and organization of the nucleus in Trypanosoma brucei.
Journal ArticleDOI
Role of the histone variant H2A.Z/Htz1p in TBP recruitment, chromatin dynamics, and regulated expression of oleate-responsive genes.
Yakun Wan,Ramsey A. Saleem,Alexander V. Ratushny,Oriol Roda,Jennifer J. Smith,Chan Hsien Lin,Chan Hsien Lin,Jung-Hsien Chiang,Jung-Hsien Chiang,John D. Aitchison +9 more
TL;DR: An analysis of the nucleosome dynamics and Htz1p association with these promoters suggests a complex mechanism in which Htz 1p-containing nucleosomes at fatty acid-responsive promoters are disassembled upon initial exposure to oleic acid leading to the loss of Htz2p from the promoter.