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Alexandre Wohlkonig
Researcher at Vrije Universiteit Brussel
Publications - 47
Citations - 2544
Alexandre Wohlkonig is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Ethionamide & Mycobacterium tuberculosis. The author has an hindex of 19, co-authored 46 publications receiving 1975 citations. Previous affiliations of Alexandre Wohlkonig include Université libre de Bruxelles & VU University Amsterdam.
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Journal ArticleDOI
Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors
Agnès Marie Joncour,Nicolas Desroy,Christopher Gaëtan Housseman,Xavier Marie Bock,Natacha Bienvenu,Laëtitia Cherel,Virginie Labeguere,Christophe Peixoto,Denis Annoot,Luce Lepissier,Jörg Heiermann,Willem Jan Hengeveld,Gregor Pilzak,Alain Monjardet,Emanuelle Wakselman,Veronique Roncoroni,Sandrine Le Tallec,R Galien,Christelle David,Nele Vandervoort,Thierry Christophe,Katja Conrath,Mia Jans,Alexandre Wohlkonig,Sameh H. Soror,Jan Steyaert,Robert Touitou,Damien Fleury,Lionel Vercheval,Patrick Mollat,Nicolas Triballeau,Ellen van der Aar,Reginald Brys,Bertrand Heckmann +33 more
TL;DR: Exploration of the structure-activity relationship led to compounds displaying high activity in biochemical and plasma assays, exemplified by compound 40, which was able to decrease the plasma LPA levels upon oral administration to rats.
Journal ArticleDOI
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
Marion Flipo,Nicolas Willand,Nathalie Lecat-Guillet,Candide Hounsou,Matthieu Desroses,Florence Leroux,Zoé Lens,Zoé Lens,Zoé Lens,Vincent Villeret,Vincent Villeret,Alexandre Wohlkonig,René Wintjens,Thierry Christophe,Hee Kyoung Jeon,Camille Locht,Priscille Brodin,Alain R. Baulard,Benoit Deprez +18 more
TL;DR: From this screening a new chemical family of EthR inhibitors bearing an N-phenylphenoxyacetamide motif was identified, and the X-ray structure of the most potent compound crystallized with EthR inspired the synthesis of a 960-member focused library.
Posted ContentDOI
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Tomasz Uchański,S. Masiulis,Baptiste Fischer,Valentina Kalichuk,Alexandre Wohlkonig,Thomas Zögg,Han Remaut,Wim F. Vranken,Wim F. Vranken,A. Radu Aricescu,A. Radu Aricescu,Els Pardon,Jan Steyaert +12 more
TL;DR: It is demonstrated that engineered Nbs can also help overcome two major obstacles that limit the resolution of single-particle cryo-EM reconstructions: particle size and preferential orientation at the water-air interface.
Journal ArticleDOI
Biphenyl 2,3′,4,5′,6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes
Fabrice Vandeput,Laurent Combettes,Stephen J. Mills,Katrien Backers,Alexandre Wohlkonig,Jan B. Parys,Humbert De Smedt,Ludwig Missiaen,Geneviève Dupont,Barry V. L. Potter,Christophe Erneux +10 more
TL;DR: The data show for the first time that the frequency of Ca2- oscillations in response to a Ca2+‐mobilizing agonist can be controlled by inhibitors of type‐I Ins(1,4,5)P3 5‐phosphatase inhibition and an inhibitory effect, which was exerted directly on the Ins( 1, 4, 5)P 3 receptor.
Journal ArticleDOI
The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins.
Hélène Hodak,Alexandre Wohlkonig,Caroline Smet-Nocca,Hervé Drobecq,Jean-Michel Wieruszeski,Magalie Sénéchal,Isabelle Landrieu,Camille Locht,Camille Locht,Marc Jamin,Françoise Jacob-Dubuisson,Françoise Jacob-Dubuisson +11 more
TL;DR: A new periplasmic PPIase of the parvulin family, Par27, which binds to an unfolded filamentous hemagglutinin fragment of Bordetella pertussis is identified by affinity chromatography.