Fabien Campagne

TL;DR: New features in the fifth major GPCRdb release are highlighted, including G PCR crystal structure browsing, superposition and display of ligand interactions, direct deposition by users of point mutations and their effects on ligand binding.

TL;DR: DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profile.

TL;DR: P predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans are generated.

TL;DR: These rules define procedures for encoding and annotating models represented in machine-readable form to enable users to have confidence that curated models are an accurate reflection of their associated reference descriptions and to facilitate model reuse and composition into large subcellular models.

TL;DR: A likely candidate is identified: T1R3, a previously unknown G protein-coupled receptor (GPCR) and the only GPCR in this region of the sequenced human genome syntenous to the region of Sac in mouse, which is the major determinant of differences between sweet-sensitive and -insensitive strains of mice in their responsiveness to saccharin, sucrose and other sweeteners.