Andreas Kupz

TL;DR: A role for the microbiota is revealed in promoting CD8+ T cell long-term survival as memory cells and it is suggested that microbial metabolites guide the metabolic rewiring of activated CD8- T cells to enable this transition.

TL;DR: DSS-induced colitis is characterized by a shift in the intestinal microflora towards pro-inflammatory Gram-negative bacteria and may serve as a biomarker for colitis severity and DSS- induced barrier damage seems to be a valuable model to further identify bacterial factors involved in maintaining intestinal homeostasis and to test therapeutic interventions based upon anti-TLR strategies.

TL;DR: The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally and due to climate change, the Tropics are expanding which will increase NTM infection regions.

TL;DR: An in-depth analysis of immunological mechanisms associated with superior mucosal protection in the mouse model of TB found that mucosal, and not subcutaneous, BCG vaccination generates lung-resident memory T cell populations that confer protection against pulmonary TB.

TL;DR: It is shown that CD8α+ DCs were particularly efficient at sensing bacterial flagellin through NLRC4 inflammasomes and only IL-18 was required for IFN-γ production by memory CD8+ T cells, which could be activated by Salmonella enterica serovar Typhimurium, Yersinia pseudotuberculosis and Pseudomonas aeruginosa.