A
Azlina Ahmad-Annuar
Researcher at University of Malaya
Publications - 58
Citations - 1802
Azlina Ahmad-Annuar is an academic researcher from University of Malaya. The author has contributed to research in topics: Population & Disease. The author has an hindex of 16, co-authored 50 publications receiving 1514 citations. Previous affiliations of Azlina Ahmad-Annuar include Queen Mary University of London & University College London.
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Journal ArticleDOI
Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport
Majid Hafezparast,Rainer Klocke,Christiana Ruhrberg,Andreas Marquardt,Azlina Ahmad-Annuar,Samantha Bowen,Giovanna Lalli,Abi S. Witherden,Holger Hummerich,Sharon E. Nicholson,P. Jeffrey Morgan,Ravi Oozageer,John V. Priestley,Sharon Averill,V.R. King,Simon T. Ball,Jo Peters,Takashi Toda,Ayumu Yamamoto,Yasushi Hiraoka,Martin Augustin,Dirk Korthaus,Sigrid Wattler,Philipp Wabnitz,Carmen Dickneite,Stefan Lampel,Florian Boehme,Gisela Peraus,Andreas Popp,Martina Rudelius,Juergen Schlegel,Helmut Fuchs,Martin Hrabé de Angelis,Giampietro Schiavo,David T. Shima,Andreas Russ,Gabriele Stumm,Joanne E. Martin,Elizabeth M. C. Fisher +38 more
TL;DR: It is shown that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology.
Journal ArticleDOI
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
Azlina Ahmad-Annuar,Lorenza Ciani,Iordanis Simeonidis,Judit Herreros,Naila Ben Fredj,Silvana B. Rosso,Anita C. Hall,Stephen G. Brickley,Patricia C. Salinas +8 more
TL;DR: It is demonstrated that Wnts signal across the synapse on Dvl-expressing presynaptic terminals to regulate synaptic assembly and suggest a potential novel function for WNTs in neurotransmitter release.
Journal ArticleDOI
Parkinson's disease in the Western Pacific Region
Shen-Yang Lim,Ai Huey Tan,Azlina Ahmad-Annuar,Christine Klein,Louis C.S. Tan,Raymond L. Rosales,Roongroj Bhidayasiri,Yih Ru Wu,Huifang Shang,Andrew Evans,Pramod Kumar Pal,Nobutaka Hattori,Chong Tin Tan,Beomseok Jeon,Eng-King Tan,Anthony E. Lang +15 more
TL;DR: Improvements in infrastructure, clinical governance, and services, and concerted collaborative efforts in training and research, including greater representation of the Western Pacific Region in clinical trials, will improve care of patients with Parkinson's disease in this region and beyond.
Journal ArticleDOI
Genome-wide association study of Parkinson's disease in East Asians.
Jia Nee Foo,Jia Nee Foo,Louis C.S. Tan,Ishak D. Irwan,Wing Lok Au,Hui Qi Low,Kumar M. Prakash,Azlina Ahmad-Annuar,Jin-Xin Bei,Anne Y.Y. Chan,Chiung Mei Chen,Yi-Chun Chen,Sun Ju Chung,Hao Deng,Shen-Yang Lim,Vincent Mok,Hao Pang,Zhong Pei,Rong Peng,Hui-Fang Shang,Kyuyoung Song,Ai Huey Tan,Yih-Ru Wu,Tin Aung,Ching-Yu Cheng,Fook Tim Chew,Soo-Hong Chew,Siow Ann Chong,Richard P. Ebstein,Jimmy Lee,Seang-Mei Saw,Adeline Seow,Mythily Subramaniam,E-Shyong Tai,Eranga N. Vithana,Tien Yin Wong,Khai Koon Heng,Wee-Yang Meah,Chiea Chuen Khor,Chiea Chuen Khor,Hong Liu,Furen Zhang,Jianjun Liu,Eng-King Tan +43 more
TL;DR: This is the first Han Chinese GWAS analysing a total of 22,729 subjects from Singapore, Hong Kong, Malaysia, Korea, mainland China and Taiwan and observes strong associations reaching genome-wide significance at SNCA, LRRK2 and MCCC1, confirming their important roles in both European and Asian PD.
Journal ArticleDOI
Improved inherited peripheral neuropathy genetic diagnosis by whole-exome sequencing
Alexander P. Drew,Danqing Zhu,Aditi Kidambi,Carolyn Ly,Shelisa Tey,Megan H. Brewer,Azlina Ahmad-Annuar,Garth A. Nicholson,Garth A. Nicholson,Marina L. Kennerson,Marina L. Kennerson +10 more
TL;DR: The advantage of using WES for genetic diagnosis in highly heterogeneous diseases such as IPNs is highlighted and has been particularly powerful in this cohort where genetic diagnosis could not be achieved due to phenotype and mode of inheritance not being previously obvious.